{"id":"W3101728747","doi":"10.1002/hep.31622","title":"Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH","year":2020,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Cirrhosis; Medicine; Gastroenterology; Internal medicine; Fibrosis; Transient elastography; Clinical endpoint; Placebo; Liver biopsy; Steatosis; Surrogate endpoint; Steatohepatitis; Liver disease; Fatty liver; Randomized controlled trial; Biopsy; Pathology; Liver fibrosis; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000476409,0.0001018252,0.0002733322,0.00004350857,0.000124894,0.00002159727,0.00002288596,0.0000458192,0.00002516531],"category_scores_gemma":[0.00008250569,0.0000910127,0.0000358487,0.00008105664,0.00003077393,0.0000532646,0.00005854018,0.00003566446,0.000005976281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003763855,"about_ca_system_score_gemma":0.00002329556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006487303,"about_ca_topic_score_gemma":0.000009717115,"domain_scores_codex":[0.9993738,0.00002063283,0.0001187636,0.0002503134,0.00006211435,0.0001743929],"domain_scores_gemma":[0.9994966,0.0001559638,0.00003261872,0.00006981772,0.00005784252,0.0001871708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002204668,0.0001387772,0.9793677,0.0002269965,0.0001626985,0.00001502382,0.001564227,3.427196e-7,0.001254104,0.000981597,0.004952979,0.01111505],"study_design_scores_gemma":[0.01224852,0.003905751,0.8944046,0.0002959,0.001005164,0.00007695689,0.0009750514,0.01005619,0.02058978,0.00114898,0.05474271,0.0005504166],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9619622,0.001989634,0.0003253082,0.03488091,0.00003980851,0.0006563705,0.0000605056,0.00004069686,0.00004457074],"genre_scores_gemma":[0.9943857,0.0003878781,0.0008211643,0.004097709,0.00003812252,0.0001926135,0.00004625259,0.00001350002,0.00001710064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08496316,"threshold_uncertainty_score":0.371139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06023962462780621,"score_gpt":0.3052502966693258,"score_spread":0.2450106720415196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}