{"id":"W3101816903","doi":"10.1038/s41467-020-19650-8","title":"Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Center for Advancing Translational Sciences; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Somatic hypermutation; Antibody; Virology; B cell; Biology; Viremia; Neutralizing antibody; Genetically engineered; Immunization; Chimeric antigen receptor; Immunology; Immune system; T cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001985979,0.0003846802,0.0001680429,0.0001975544,0.000106877,0.0002840908,0.0001766173,0.0003359882,0.00121441],"category_scores_gemma":[0.0001538574,0.0001325759,0.0001710118,0.00008871649,0.0001381595,0.0001555567,0.0003237218,0.000683979,0.0003167611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001710258,"about_ca_system_score_gemma":0.0001533403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002168593,"about_ca_topic_score_gemma":0.0003845457,"domain_scores_codex":[0.999867,0.00002972451,0.00001071805,0.00002336971,0.00003107434,0.00003808365],"domain_scores_gemma":[0.9999145,0.00002461835,0.00001867935,0.00001231878,0.0000107771,0.00001907955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003527004,0.00004758071,0.00007745647,0.00002987121,0.000004005065,0.00002500977,0.00001137597,0.0001444568,0.9973591,0.0001891195,0.00006027933,0.002016381],"study_design_scores_gemma":[0.00003442403,0.0005382411,0.0007051449,0.00001082484,0.00001334117,0.0002112975,0.00001291973,0.0009941151,0.992991,0.0001013909,0.004384416,0.000002843625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730637,0.001631708,0.02066636,0.0002233618,0.0001028258,0.000169352,0.0003414579,0.0001788837,0.003622419],"genre_scores_gemma":[0.9803196,0.001255866,0.01366456,0.0002169301,0.00002863834,0.00009468564,0.0005172694,0.00003604498,0.003866512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00121441,"threshold_uncertainty_score":0.004062593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424742896324425,"score_gpt":0.2958920426905656,"score_spread":0.2716446137273213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}