{"id":"W3101841106","doi":"10.1177/0192623320960023","title":"Case Studies Discussing the Pathology, Immunogenicity, and Proposed Mechanism of Toxicity of an Inhaled Anti-TGFβ Humanized Fab Antibody in Non-Human Primates and Mice","year":2020,"lang":"en","type":"article","venue":"Toxicologic Pathology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Immunogenicity; Pathology; Antibody; Bronchoalveolar lavage; Lymph; Immunology; CD68; CD8; Inflammation; Immune system; Histopathology; Medicine; Immunohistochemistry; Lung; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004364444,0.001267182,0.0004615852,0.001348588,0.001515418,0.0008272348,0.0008792141,0.002983449,0.002084184],"category_scores_gemma":[0.001126698,0.0005189177,0.0007568947,0.000772221,0.001149197,0.0009309217,0.000633682,0.001703596,0.000605694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009295687,"about_ca_system_score_gemma":0.0003435876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002081765,"about_ca_topic_score_gemma":0.002354487,"domain_scores_codex":[0.9996766,0.00006529283,0.00003484184,0.00007147295,0.00005109131,0.0001007388],"domain_scores_gemma":[0.9994936,0.0001800863,0.0001269752,0.00007450071,0.00003301699,0.0000917373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0002700069,0.0002506346,0.009442971,0.0001690795,0.00003901715,0.9724099,0.0007503158,0.00034582,0.006973952,0.001723911,0.0007537676,0.006870507],"study_design_scores_gemma":[0.00001594509,0.0002916286,0.002562958,0.00003800818,0.00003674395,0.9883011,0.0001728165,0.0002806769,0.003615415,0.00047385,0.00419981,0.00001113347],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9295584,0.02233984,0.01322926,0.002319307,0.0002996161,0.0004685164,0.0003687586,0.000267084,0.03114929],"genre_scores_gemma":[0.9849627,0.007016416,0.00256821,0.0006016647,0.0003085595,0.00006727779,0.0001316588,0.00001590691,0.00432763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002983449,"threshold_uncertainty_score":0.006972313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04703134242117983,"score_gpt":0.3529460337776425,"score_spread":0.3059146913564627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}