{"id":"W3101841106","doi":"10.1177/0192623320960023","title":"Case Studies Discussing the Pathology, Immunogenicity, and Proposed Mechanism of Toxicity of an Inhaled Anti-TGFβ Humanized Fab Antibody in Non-Human Primates and Mice","year":2020,"lang":"en","type":"article","venue":"Toxicologic Pathology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Immunogenicity; Pathology; Antibody; Bronchoalveolar lavage; Lymph; Immunology; CD68; CD8; Inflammation; Immune system; Histopathology; Medicine; Immunohistochemistry; Lung; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008309931,0.0002253601,0.0008944388,0.0001431704,0.0001931847,0.000008834526,0.0001174237,0.0002445726,0.00001746938],"category_scores_gemma":[0.0003194423,0.0001376516,0.00006327797,0.0002005182,0.001060277,0.00008738662,0.0002821766,0.0003140901,0.000001038716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002546086,"about_ca_system_score_gemma":0.00004863372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008543852,"about_ca_topic_score_gemma":0.00002603414,"domain_scores_codex":[0.9980102,0.0005682895,0.0006327812,0.0004103439,0.0001199887,0.0002584343],"domain_scores_gemma":[0.9990529,0.0001500053,0.0003429913,0.0002371488,0.0001400903,0.00007689315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001727843,0.0003223282,0.00393815,0.000300569,0.0000541236,0.00785802,0.006067062,0.000003547234,0.9803779,0.0004932843,0.000002692975,0.0004095688],"study_design_scores_gemma":[0.01015842,0.007219062,0.06385604,0.0001656736,0.0004994747,0.02539194,0.01681678,0.001913421,0.8724717,0.00097948,0.000006052405,0.0005219718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974537,0.000793295,0.00006476913,0.0006133072,0.00006106342,0.0008583121,0.00001851594,0.0000373103,0.00009973307],"genre_scores_gemma":[0.9982935,0.0001621412,0.0005793473,0.0008831652,0.00003515916,0.000009536959,0.00001136555,0.00001551154,0.00001031594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1079062,"threshold_uncertainty_score":0.5613269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04703134242117983,"score_gpt":0.3529460337776425,"score_spread":0.3059146913564627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}