{"id":"W3101884091","doi":"10.1038/s41588-020-00725-7","title":"Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors","year":2020,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":346,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University; Montreal Neurological Institute and Hospital","funders":"National Key Research and Development Program of China; European Regional Development Fund; Medical Research Council; Centre hospitalier régional universitaire de Lille; Schweizerische Akademie der Medizinischen Wissenschaften; Centers for Disease Control and Prevention; Biomedicum Helsinki-säätiö; Suomen Lääketieteen Säätiö; Päivikki ja Sakari Sohlbergin Säätiö; National Natural Science Foundation of China; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut National de la Santé et de la Recherche Médicale; European Commission; Schweizerische Herzstiftung; Aarne ja Aili Turusen Säätiö; University of Oxford; National Institute of Neurological Disorders and Stroke; British Heart Foundation; Agence Nationale de la Recherche; Cancer Research UK; Wellcome Trust; Fondation de France; National Institute for Health and Care Research; Emil Aaltosen Säätiö; Maud Kuistilan Muistosäätiö; Alfred Kordelinin Säätiö; Aarne Koskelon Säätiö; Eli Lilly and Company; Canadian Institutes of Health Research; Uniwersytet Jagielloński Collegium Medicum; Helsingin ja Uudenmaan Sairaanhoitopiiri; GlaxoSmithKline; National Science Foundation","keywords":"Genome-wide association study; Genetic architecture; Biology; Subarachnoid hemorrhage; Aneurysm; Heritability; Pleiotropy; Genetic association; Disease; Quantitative trait locus; Genetics; Internal medicine; Single-nucleotide polymorphism; Gene; Medicine; Genotype; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006751,0.0009023623,0.0007204312,0.002149387,0.0007015052,0.0009635799,0.000810745,0.001446576,0.002692769],"category_scores_gemma":[0.00315851,0.0004952973,0.001270985,0.002940782,0.0008298474,0.0003390374,0.0007614953,0.001095633,0.0002820556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000253597,"about_ca_system_score_gemma":0.0005184661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002769432,"about_ca_topic_score_gemma":0.002754059,"domain_scores_codex":[0.9984112,0.000569546,0.0001664511,0.0004267808,0.0002433764,0.0001825916],"domain_scores_gemma":[0.9968402,0.001403359,0.0009867691,0.0002487723,0.0001859528,0.0003348142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001750601,0.0001264721,0.9776126,0.00005983621,0.00172041,0.001794728,0.0002147784,0.0002768878,0.008951203,0.0003820585,0.0005580356,0.006552513],"study_design_scores_gemma":[0.000109917,0.0001273393,0.9938661,0.00002551838,0.0008272487,0.002627274,0.00014554,0.0005994933,0.0007144049,0.0004567031,0.0004826452,0.00001776989],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954717,0.0014649,0.001188487,0.0003545977,0.0000439758,0.000009636243,0.0003966563,0.00003556131,0.001034483],"genre_scores_gemma":[0.9980585,0.0004092983,0.0008372773,0.00007287918,0.00005436459,0.000009505224,0.0002897689,0.00001626314,0.0002520818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002769432,"threshold_uncertainty_score":0.009008169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515633204648634,"score_gpt":0.2774301259424519,"score_spread":0.2622737938959655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}