{"id":"W3101884091","doi":"10.1038/s41588-020-00725-7","title":"Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors","year":2020,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":346,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University; Montreal Neurological Institute and Hospital","funders":"National Key Research and Development Program of China; European Regional Development Fund; Medical Research Council; Centre hospitalier régional universitaire de Lille; Schweizerische Akademie der Medizinischen Wissenschaften; Centers for Disease Control and Prevention; Biomedicum Helsinki-säätiö; Suomen Lääketieteen Säätiö; Päivikki ja Sakari Sohlbergin Säätiö; National Natural Science Foundation of China; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut National de la Santé et de la Recherche Médicale; European Commission; Schweizerische Herzstiftung; Aarne ja Aili Turusen Säätiö; University of Oxford; National Institute of Neurological Disorders and Stroke; British Heart Foundation; Agence Nationale de la Recherche; Cancer Research UK; Wellcome Trust; Fondation de France; National Institute for Health and Care Research; Emil Aaltosen Säätiö; Maud Kuistilan Muistosäätiö; Alfred Kordelinin Säätiö; Aarne Koskelon Säätiö; Eli Lilly and Company; Canadian Institutes of Health Research; Uniwersytet Jagielloński Collegium Medicum; Helsingin ja Uudenmaan Sairaanhoitopiiri; GlaxoSmithKline; National Science Foundation","keywords":"Genome-wide association study; Genetic architecture; Biology; Subarachnoid hemorrhage; Aneurysm; Heritability; Pleiotropy; Genetic association; Disease; Quantitative trait locus; Genetics; Internal medicine; Single-nucleotide polymorphism; Gene; Medicine; Genotype; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352088,0.0002439956,0.0004814851,0.00005964743,0.0001602921,0.00003796175,0.0001361296,0.0003429564,0.00003384195],"category_scores_gemma":[0.0004851848,0.0001880492,0.0001006491,0.0002728034,0.00007660239,0.00003251883,0.00005968819,0.0008989563,0.000008746429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000457825,"about_ca_system_score_gemma":0.00006172066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000470979,"about_ca_topic_score_gemma":0.0001062755,"domain_scores_codex":[0.9981118,0.0001629161,0.0005284317,0.0004654916,0.0004995197,0.0002317976],"domain_scores_gemma":[0.998387,0.0003463536,0.0004832974,0.0003179496,0.0002652745,0.0002000953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003037872,0.0006596441,0.9959379,0.00002673016,0.0003856057,0.00005750426,0.0012541,0.0000976592,0.0002686652,0.000001275132,0.0002790985,0.0007280369],"study_design_scores_gemma":[0.002416166,0.00334158,0.990926,0.000006538233,0.001518146,0.0000132901,0.0006455769,0.0002447179,0.0002094174,0.00006749039,0.0004399162,0.0001711603],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973107,0.0007643514,0.000113996,0.0005316229,0.0001293281,0.000901914,0.00009047687,0.00005455985,0.0001030648],"genre_scores_gemma":[0.9971237,0.0009172263,0.001031587,0.0003260392,0.0004030832,0.00001217838,0.00004990075,0.00003331918,0.000102948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005011893,"threshold_uncertainty_score":0.7668424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515633204648634,"score_gpt":0.2774301259424519,"score_spread":0.2622737938959655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}