{"id":"W3101956347","doi":"10.1093/braincomms/fcaa167","title":"Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways","year":2020,"lang":"en","type":"article","venue":"Brain Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Alzheimer’s Society","keywords":"Neuropathology; Dementia; Apolipoprotein E; Alzheimer's disease; Tauopathy; Disease; Clinical Dementia Rating; Psychology; Cognitive decline; Neuroscience; Medicine; Pathology; Neurodegeneration","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001312669,0.0005841851,0.0003906091,0.0007986032,0.0003683051,0.0008157149,0.0003663565,0.000395252,0.001953455],"category_scores_gemma":[0.003218856,0.0002652328,0.0008181796,0.0005997751,0.0006086427,0.0003555526,0.0006398332,0.000538987,0.0001833334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002309183,"about_ca_system_score_gemma":0.0003946823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002917902,"about_ca_topic_score_gemma":0.00264079,"domain_scores_codex":[0.9989733,0.0004654386,0.00006072695,0.0002128906,0.0001781913,0.0001095081],"domain_scores_gemma":[0.9971112,0.001575162,0.0006633389,0.0002503564,0.0002017696,0.0001981582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007564566,0.0001011857,0.9808903,0.00003209417,0.0006066049,0.0005667841,0.0002046207,0.0004573197,0.009975448,0.0002708035,0.0001009078,0.00603749],"study_design_scores_gemma":[0.00001121224,0.0001629519,0.9967858,0.00001237325,0.0001588479,0.0004096216,0.0001006198,0.0007623479,0.0008216258,0.0006515995,0.0001146135,0.000008317656],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997574,0.0004614486,0.001122053,0.00008307995,0.000005935257,0.00001061583,0.0001768082,0.000008809752,0.0005572687],"genre_scores_gemma":[0.999027,0.0001726707,0.0004291877,0.00002197656,0.000007370792,0.00000649604,0.000112032,0.00000310399,0.0002201109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002917902,"threshold_uncertainty_score":0.006942153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1695738217078563,"score_gpt":0.3642613158248365,"score_spread":0.1946874941169802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}