{"id":"W3102011969","doi":"10.1101/2020.11.16.384321","title":"Hexarelin exerts neuroprotective and antioxidant effects against hydrogen peroxide-induced toxicity through the modulation of MAPK and PI3K/Akt patways in Neuro-2A cells","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Medicinal Plants and Neuroprotection","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"","keywords":"Neuroprotection; Chemistry; Protein kinase B; Oxidative stress; Viability assay; Apoptosis; PI3K/AKT/mTOR pathway; Reactive oxygen species; Pharmacology; Nitric oxide; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010355,0.0005277115,0.0002977449,0.0002983448,0.0001861796,0.0002161598,0.0001757742,0.0002692534,0.001225492],"category_scores_gemma":[0.00006309825,0.0001356747,0.0003314556,0.0002112924,0.0001622938,0.0002093169,0.0001111172,0.0004785593,0.0001834904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001906744,"about_ca_system_score_gemma":0.0001889008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007541907,"about_ca_topic_score_gemma":0.001422215,"domain_scores_codex":[0.9999402,0.000009075235,0.000009227666,0.00000911084,0.0000138337,0.00001862233],"domain_scores_gemma":[0.9999439,0.000006721385,0.00001880398,0.000005605274,0.000007598806,0.00001737251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004853674,0.00008275252,0.0001219827,0.00008341666,0.00001157828,0.000082698,0.00001467154,0.00006724961,0.9979082,0.00002634224,0.00004172471,0.001074118],"study_design_scores_gemma":[0.0001233687,0.00237731,0.009365108,0.00001917528,0.00006879049,0.0003238282,0.00009746054,0.0006756327,0.9851568,0.00007246887,0.001710221,0.000009959098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957119,0.002193489,0.0006373275,0.00009000587,0.00003437988,0.00002531421,0.0004114401,0.00005101769,0.0008449706],"genre_scores_gemma":[0.9926772,0.002869114,0.001421516,0.0001043145,0.0000171151,0.00005564793,0.0007943325,0.000009862974,0.00205072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225492,"threshold_uncertainty_score":0.004099727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852323121207055,"score_gpt":0.2226111715468409,"score_spread":0.2040879403347703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}