{"id":"W3102021866","doi":"10.1101/2020.06.18.158154","title":"Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Mount Sinai Hospital; Sunnybrook Health Science Centre; St. Michael's Hospital; Vector Institute; Sunnybrook Hospital; University of Waterloo; McMaster University Medical Centre; University Health Network; Hamilton Health Sciences; University of Toronto; McMaster University; University of British Columbia","funders":"Canadian Institutes of Health Research; Zhejiang University; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; McMaster University","keywords":"Interferon; Biology; In vitro; Virology; Immunology; Interferon type I; Stimulation; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Severe acute respiratory syndrome coronavirus; Virus; Coronavirus disease 2019 (COVID-19); Medicine; Genetics; Neuroscience; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006109826,0.0003021162,0.0001328429,0.0003228382,0.0002155876,0.0001961095,0.000164508,0.0003153419,0.006780093],"category_scores_gemma":[0.0003186062,0.00008917127,0.0002933122,0.0001458813,0.0005910624,0.0001606815,0.0001960299,0.0005947539,0.001056756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002384921,"about_ca_system_score_gemma":0.0002709437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000206838,"about_ca_topic_score_gemma":0.0002469083,"domain_scores_codex":[0.9996449,0.0001161321,0.00003547462,0.0000588318,0.0000855858,0.00005903243],"domain_scores_gemma":[0.9995115,0.0001794198,0.00008144061,0.0001243243,0.00004587938,0.00005740225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004689125,0.0001416321,0.001919527,0.0001404264,0.00001431009,0.0001453871,0.00002060173,0.00004281119,0.9941361,0.0006579905,0.0002327366,0.00207952],"study_design_scores_gemma":[0.00006865891,0.001647283,0.01771964,0.00004898766,0.00002876276,0.002435021,0.00008886903,0.000399019,0.9691237,0.0007071227,0.007723616,0.000009266187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655263,0.006138905,0.007103271,0.0006667632,0.0002070213,0.0001196341,0.001964384,0.0001557808,0.0181178],"genre_scores_gemma":[0.988645,0.001949765,0.003532129,0.000241941,0.0001088869,0.0000919607,0.001995646,0.00001827112,0.003416406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006780093,"threshold_uncertainty_score":0.02268165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04777774005929896,"score_gpt":0.2985252761374411,"score_spread":0.2507475360781421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}