{"id":"W3102021866","doi":"10.1101/2020.06.18.158154","title":"Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Mount Sinai Hospital; Sunnybrook Health Science Centre; St. Michael's Hospital; Vector Institute; Sunnybrook Hospital; University of Waterloo; McMaster University Medical Centre; University Health Network; Hamilton Health Sciences; University of Toronto; McMaster University; University of British Columbia","funders":"Canadian Institutes of Health Research; Zhejiang University; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; McMaster University","keywords":"Interferon; Biology; In vitro; Virology; Immunology; Interferon type I; Stimulation; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Severe acute respiratory syndrome coronavirus; Virus; Coronavirus disease 2019 (COVID-19); Medicine; Genetics; Neuroscience; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002870466,0.0003560915,0.0006046827,0.0002843274,0.00007255455,0.00002780134,0.0002738219,0.0004919479,0.00004530367],"category_scores_gemma":[0.0008451624,0.0003590448,0.0001195697,0.000236976,0.0002473182,0.0001754044,0.0005060898,0.0006949179,0.0000280617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001182306,"about_ca_system_score_gemma":0.0003487221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002236954,"about_ca_topic_score_gemma":8.68689e-7,"domain_scores_codex":[0.9981594,0.0004425774,0.0005613757,0.0005205252,0.00007460321,0.0002414964],"domain_scores_gemma":[0.9983001,0.0002380353,0.0005223412,0.0005254327,0.0003919105,0.00002216067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003683817,0.0001093172,0.001014142,0.0002955026,0.0002590027,0.000002196324,0.00008418648,3.591794e-7,0.9943045,0.0001161477,0.0001269127,0.000003860471],"study_design_scores_gemma":[0.0004483174,0.0008384463,0.03840322,0.001160939,0.00005625874,7.311402e-8,0.00001248623,0.00001139656,0.9584864,4.258498e-7,0.0002941784,0.0002878464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893339,0.008499185,0.00007056329,0.0001052885,0.001484966,0.0003859135,0.0000251142,0.00009274237,0.000002272679],"genre_scores_gemma":[0.9994382,0.0002229201,0.0001151474,0.0001043703,0.00003976349,0.00002894764,4.920859e-7,0.00004384534,0.000006346041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03738908,"threshold_uncertainty_score":0.9998862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04777774005929896,"score_gpt":0.2985252761374411,"score_spread":0.2507475360781421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}