{"id":"W3102072634","doi":"10.1101/gad.340281.120","title":"BMP signaling: at the gate between activated melanocyte stem cells and differentiation","year":2020,"lang":"en","type":"article","venue":"Genes & Development","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Melanoma Research Alliance; Burroughs Wellcome Fund; Weill Cornell Medical College; Howard Hughes Medical Institute","keywords":"Biology; Wnt signaling pathway; Microphthalmia-associated transcription factor; Cell biology; Stem cell; Transcription factor; Hair follicle; Cellular differentiation; Melanocyte; Chromatin; Proto-Oncogene Proteins c-kit; Signal transduction; Stem cell factor; Genetics; Gene; Haematopoiesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159226,0.0001699886,0.0001452,0.0001879637,0.0002118431,0.000579607,0.0002021192,0.0002495752,0.001114807],"category_scores_gemma":[0.0001136657,0.0001451925,0.0001136762,0.00009551806,0.0003761789,0.0004826178,0.0003177726,0.0005128021,0.0003465303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004401573,"about_ca_system_score_gemma":0.000285684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006350965,"about_ca_topic_score_gemma":0.001387706,"domain_scores_codex":[0.9999051,0.00001059586,0.000003907483,0.00002069474,0.00003997589,0.00001974974],"domain_scores_gemma":[0.9999347,0.00001012425,0.00001468744,0.000005626603,0.000007843058,0.00002700839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005787267,0.000004610834,0.0004972426,0.000018837,0.000002120086,0.00008629288,0.00002893202,0.00005594681,0.9949753,0.002086345,0.00004276532,0.00214362],"study_design_scores_gemma":[0.00001315971,0.000100522,0.01310496,0.00002301604,0.00001146794,0.0003655386,0.0001335104,0.002029725,0.9756193,0.001602255,0.006989909,0.000006647978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684183,0.003897542,0.01966333,0.000454476,0.00006544607,0.00003439014,0.0003831364,0.0002465712,0.006836792],"genre_scores_gemma":[0.9900734,0.001116648,0.004731148,0.0001075025,0.00001988116,0.0000137279,0.0001301216,0.00003403234,0.003773516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114807,"threshold_uncertainty_score":0.003729403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02475398063798694,"score_gpt":0.2310940380814474,"score_spread":0.2063400574434604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}