{"id":"W3102146372","doi":"10.1136/bmjopen-2020-040110","title":"Efficacy of pragmatic same-day ring prophylaxis for adult individuals exposed to SARS-CoV-2 in Switzerland (COPEP): protocol of an open-label cluster randomised trial","year":2020,"lang":"en","type":"article","venue":"BMJ Open","topic":"SARS-CoV-2 detection and testing","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"Fondation privée des Hôpitaux universitaires de Genève","keywords":"Medicine; Lopinavir; Asymptomatic; Incidence (geometry); Pre-exposure prophylaxis; Ritonavir; Clinical endpoint; Post-exposure prophylaxis; Intention-to-treat analysis; Randomized controlled trial; Cluster (spacecraft); Internal medicine; Trial registration; Chemoprophylaxis; Pediatrics; Coronavirus disease 2019 (COVID-19); Viral load; Immunology; Human immunodeficiency virus (HIV); Antiretroviral therapy; Men who have sex with men; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01922625,0.005509405,0.007980596,0.001363809,0.001981078,0.003586762,0.003193548,0.006113708,0.0414505],"category_scores_gemma":[0.0160641,0.002315715,0.004948408,0.001804529,0.003533716,0.002764731,0.001921378,0.006009153,0.008621292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004622483,"about_ca_system_score_gemma":0.01154383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002990866,"about_ca_topic_score_gemma":0.00451485,"domain_scores_codex":[0.9887992,0.007032656,0.0008240711,0.001114237,0.0008676882,0.001362216],"domain_scores_gemma":[0.9921103,0.001740604,0.001623446,0.001078959,0.001604266,0.001842344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9599341,0.01332802,0.0004799208,0.005161219,0.001037435,0.0001220879,0.000277351,0.001670096,0.001219667,0.001115379,0.004623582,0.01103109],"study_design_scores_gemma":[0.9485027,0.03931489,0.001299178,0.0006099591,0.0004612224,0.00003311817,0.00008953252,0.0008370038,0.0003007552,0.0009390542,0.007550228,0.00006242986],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01274906,0.0003281832,0.001029136,0.000387069,0.0003949135,0.9822389,0.001516361,0.00008210669,0.001274235],"genre_scores_gemma":[0.01388742,0.0002586112,0.00165525,0.0003966836,0.0001455755,0.98225,0.0004760219,0.000009452209,0.0009208953],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0414505,"threshold_uncertainty_score":0.1386657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1856027192088415,"score_gpt":0.4512457812521282,"score_spread":0.2656430620432867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}