{"id":"W3102210030","doi":"10.15252/embj.2019103303","title":"Site‐specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling","year":2020,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"T. Von Zastrow Foundation; Österreichischen Akademie der Wissenschaften; European Commission; Japan Society for the Promotion of Science; Austrian Science Fund; AstraZeneca; Ministry of Education, Culture, Sports, Science and Technology; FP7 Ideas: European Research Council; Francis Crick Institute; University of Oxford","keywords":"Biology; Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; Cell biology; Signal transduction; Immune system; DNA ligase; Signaling proteins; Apoptosis; Genetics; Cancer research; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001685058,0.0002775302,0.0003039542,0.0002823133,0.0003571483,0.0007198776,0.0003287563,0.0003881551,0.001956411],"category_scores_gemma":[0.000196023,0.0001899176,0.00028579,0.0002257717,0.0003056163,0.0005156922,0.0004393125,0.0006665581,0.0007315219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005912601,"about_ca_system_score_gemma":0.0002234517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003432308,"about_ca_topic_score_gemma":0.0007597791,"domain_scores_codex":[0.9997831,0.00002342997,0.00001123273,0.00004462879,0.00004595719,0.0000916917],"domain_scores_gemma":[0.9998538,0.00001176473,0.00004356007,0.00001948582,0.00002828836,0.0000431353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004087969,0.00004330223,0.001686158,0.00005261783,0.00002166213,0.0001696561,0.00001777784,0.000162399,0.9904554,0.000816698,0.0003649388,0.005800627],"study_design_scores_gemma":[0.00003046023,0.0001497315,0.03837052,0.000009657792,0.00003136155,0.0009189536,0.0001018395,0.00169042,0.9537712,0.0005771056,0.004334444,0.00001423925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826873,0.007683451,0.004559024,0.0004598018,0.00006501561,0.00001852208,0.000514392,0.0001442154,0.003868278],"genre_scores_gemma":[0.9944084,0.00125134,0.0008558187,0.00007432432,0.00001740974,0.000006583775,0.0003959676,0.00002126126,0.002968878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001956411,"threshold_uncertainty_score":0.006544828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612529883872423,"score_gpt":0.2180524439382638,"score_spread":0.2019271450995396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}