{"id":"W3102210030","doi":"10.15252/embj.2019103303","title":"Site‐specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling","year":2020,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"T. Von Zastrow Foundation; Österreichischen Akademie der Wissenschaften; European Commission; Japan Society for the Promotion of Science; Austrian Science Fund; AstraZeneca; Ministry of Education, Culture, Sports, Science and Technology; FP7 Ideas: European Research Council; Francis Crick Institute; University of Oxford","keywords":"Biology; Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; Cell biology; Signal transduction; Immune system; DNA ligase; Signaling proteins; Apoptosis; Genetics; Cancer research; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003830829,0.00009058317,0.0001015797,0.00001235916,0.0002155736,0.00004525982,0.0002199384,0.00004960274,0.0001034265],"category_scores_gemma":[0.00009241021,0.00005339432,0.00009597962,0.00007239346,0.00009392877,0.000003771373,0.0001226116,0.0001590742,0.000004749775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004748763,"about_ca_system_score_gemma":0.00002912866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001969338,"about_ca_topic_score_gemma":3.115441e-7,"domain_scores_codex":[0.9992844,0.0001337786,0.0002103964,0.0001113685,0.000132342,0.000127725],"domain_scores_gemma":[0.9994948,0.0000217484,0.0001817598,0.0001558464,0.00008636534,0.00005949993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006854676,0.000009852046,0.00007838997,0.00001180078,0.000023346,5.076764e-7,0.0004243835,0.00004798698,0.9964589,0.00009565263,0.0009012875,0.001879306],"study_design_scores_gemma":[0.0002776442,0.0001386756,0.0004501044,0.00003054928,0.00001846646,0.00005379918,0.0001964259,0.00005499913,0.9937742,0.0003716344,0.004562838,0.00007062782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937204,0.002654827,0.0001015973,0.00257789,0.00006279014,0.00009982495,0.00000822504,0.000004149505,0.0007702916],"genre_scores_gemma":[0.9986445,0.0002893954,0.000128442,0.000288388,0.0004411759,0.000002534903,0.000005362879,0.00001182882,0.0001884138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004924054,"threshold_uncertainty_score":0.2177357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612529883872423,"score_gpt":0.2180524439382638,"score_spread":0.2019271450995396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}