{"id":"W3102265121","doi":"10.1002/adtp.202000196","title":"VCAM‐1‐Targeted Gene Delivery Nanoparticles Localize to Inflamed Endothelial Cells and Atherosclerotic Plaques","year":2020,"lang":"en","type":"article","venue":"Advanced Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Endothelial stem cell; Context (archaeology); VCAM-1; Endothelium; Gene delivery; Transfection; Cancer research; Chemistry; Medicine; Cell biology; Cell adhesion; Cell; Biology; Biochemistry; In vitro; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004725256,0.0002175639,0.0001840541,0.00002374967,0.00007408838,0.00003594313,0.000199655,0.0001061834,0.00001524091],"category_scores_gemma":[0.00001883523,0.0002074782,0.00006127691,0.00009447552,0.00007957146,0.00001058387,0.000124578,0.00008494912,0.0000525622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009835021,"about_ca_system_score_gemma":0.00003651568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006089548,"about_ca_topic_score_gemma":0.00001166209,"domain_scores_codex":[0.9988846,0.00005024274,0.0002256492,0.0004095967,0.000120015,0.0003098898],"domain_scores_gemma":[0.9994118,0.00001859275,0.00005720811,0.0002415102,0.00008343222,0.0001875164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003719788,0.00002737137,0.0003163485,0.00001090903,0.00007196252,0.000003909947,0.0003352214,0.0006798656,0.9792826,0.00001303856,0.00004199385,0.01884487],"study_design_scores_gemma":[0.0006687919,0.0007938992,0.0004153342,0.00001097183,0.00002663685,0.000003208603,0.0001378613,0.0002415124,0.9470316,0.00006352023,0.05034905,0.0002576753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955394,0.001399217,0.002097716,0.0004365628,0.0001212963,0.0002541648,0.00006502599,0.00003836232,0.00004829076],"genre_scores_gemma":[0.986954,0.001618249,0.002831229,0.008250396,0.0001703744,0.00002276167,0.0000231397,0.00003850094,0.00009131977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05030705,"threshold_uncertainty_score":0.8460715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01790812132001806,"score_gpt":0.2398057164426916,"score_spread":0.2218975951226735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}