{"id":"W3102265121","doi":"10.1002/adtp.202000196","title":"VCAM‐1‐Targeted Gene Delivery Nanoparticles Localize to Inflamed Endothelial Cells and Atherosclerotic Plaques","year":2020,"lang":"en","type":"article","venue":"Advanced Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Endothelial stem cell; Context (archaeology); VCAM-1; Endothelium; Gene delivery; Transfection; Cancer research; Chemistry; Medicine; Cell biology; Cell adhesion; Cell; Biology; Biochemistry; In vitro; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001694576,0.0002582555,0.0002619594,0.0002535458,0.0001277451,0.0003376727,0.0001567341,0.0003821072,0.0005002409],"category_scores_gemma":[0.0001621058,0.0001719369,0.0001071703,0.00007766212,0.0002520971,0.0001864443,0.0001439599,0.0003259457,0.0001448178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002919741,"about_ca_system_score_gemma":0.0001779875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005116669,"about_ca_topic_score_gemma":0.0005249115,"domain_scores_codex":[0.9998939,0.00001674445,0.000005277435,0.00003019793,0.00002547224,0.00002836541],"domain_scores_gemma":[0.9999138,0.00002857395,0.00001892333,0.000007964683,0.00001479246,0.00001594947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001094206,0.000006671488,0.00004774006,0.000009656683,0.000001228105,0.00001787328,0.000007371802,0.00003799489,0.9993764,0.00006167033,0.000008792585,0.000413763],"study_design_scores_gemma":[0.000006452311,0.0001336155,0.001366925,0.000004403998,0.000008024686,0.000136852,0.00001263312,0.00133091,0.996214,0.00005520457,0.000728248,0.000002711582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870691,0.00189925,0.009794473,0.00009716574,0.00002871198,0.00002407979,0.00003424733,0.00007141407,0.0009815737],"genre_scores_gemma":[0.9920351,0.0006170141,0.005054678,0.00007378705,0.00001479829,0.00002597741,0.00005768603,0.00001498586,0.002105933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005116669,"threshold_uncertainty_score":0.002118409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01790812132001806,"score_gpt":0.2398057164426916,"score_spread":0.2218975951226735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}