{"id":"W3102291668","doi":"10.1002/alz.12209","title":"Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; University of Toronto; Western University; McGill University Health Centre; Sunnybrook Health Science Centre; Toronto Western Hospital; Université Laval","funders":"Medical Research Council; Demensfonden; EU Joint Programme – Neurodegenerative Disease Research; Karolinska Institutet; Instituto de Salud Carlos III; ZonMw; Deutsche Forschungsgemeinschaft; Vetenskapsrådet; Ministero della Salute; Canadian Institutes of Health Research; Weston Brain Institute; Guarantors of Brain; British Academy; Stockholms Läns Landsting; National Institute for Health and Care Research; Wellcome Trust","keywords":"Frontotemporal dementia; Cognition; Atrophy; Dementia; Neuroscience; Psychology; Functional magnetic resonance imaging; Disease; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003677887,0.0002833504,0.0001848376,0.0007202561,0.0002982236,0.0002508909,0.0001922368,0.0002357961,0.00070197],"category_scores_gemma":[0.001598328,0.0001172954,0.0001091581,0.0003396528,0.0003476796,0.0002259149,0.0002137216,0.000146018,0.0000493091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002987563,"about_ca_system_score_gemma":0.0001294741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004371075,"about_ca_topic_score_gemma":0.008980878,"domain_scores_codex":[0.9998982,0.00002836653,0.000008372115,0.0000295104,0.00001521289,0.00002026559],"domain_scores_gemma":[0.9995239,0.000155013,0.0002041811,0.00002794131,0.00003378017,0.00005505405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009957055,0.0001312154,0.9733766,0.00003273719,0.0001667906,0.001081853,0.0007756789,0.0004686598,0.01492356,0.0001036013,0.0001155863,0.007828037],"study_design_scores_gemma":[0.000005019116,0.00008382756,0.9985273,0.000001821962,0.00002000306,0.00046847,0.00009047563,0.0004004983,0.0003029998,0.00007473068,0.00002295929,0.000001831222],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998871,0.0000163202,0.00003121085,0.000003727863,1.769683e-7,7.074705e-7,0.00001749573,7.257839e-7,0.00004252897],"genre_scores_gemma":[0.9998776,0.00001049126,0.00005066842,0.000001798067,6.918653e-7,0.000001366651,0.00003777957,4.205734e-7,0.00001916293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004371075,"threshold_uncertainty_score":0.008691251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0533434756685239,"score_gpt":0.2633749590612713,"score_spread":0.2100314833927474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}