{"id":"W3102349308","doi":"10.7554/elife.54916","title":"Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta","keywords":"Disinhibition; Potassium channel; Cell biology; HEK 293 cells; Ion channel; Gating; Biology; Chemistry; Neuroscience; Biochemistry; Biophysics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001375196,0.0001678802,0.0001730095,0.000103788,0.0001219388,0.0002734381,0.0001570695,0.0001820612,0.00052248],"category_scores_gemma":[0.0001438729,0.00007048128,0.0001798703,0.00008756193,0.0002310387,0.0001607728,0.0001792955,0.0001898283,0.0001278917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003469068,"about_ca_system_score_gemma":0.0001568514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001073497,"about_ca_topic_score_gemma":0.001631416,"domain_scores_codex":[0.9998527,0.00003112369,0.00001691642,0.0000297975,0.00004024319,0.00002916379],"domain_scores_gemma":[0.9999193,0.00001892484,0.00002405637,0.000008692316,0.00001311204,0.00001590847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002146248,0.000001875006,0.0001975478,0.00000951141,0.000002014331,0.00002154463,0.000005680508,0.00004295508,0.999255,0.00005849149,0.000008292472,0.0003755273],"study_design_scores_gemma":[0.000004553066,0.00005882709,0.008140416,0.000003592156,0.00000851736,0.0002035713,0.00002789179,0.001606446,0.9886631,0.00005478609,0.001222217,0.000006044005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963132,0.0006772621,0.002200016,0.00006699654,0.000008057265,0.000005962101,0.00009896085,0.00003369109,0.0005958673],"genre_scores_gemma":[0.9982103,0.0002330723,0.001114549,0.00003704479,0.000002001853,0.000004525805,0.00009119298,0.000009331048,0.0002979875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001073497,"threshold_uncertainty_score":0.002517045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078555019735127,"score_gpt":0.2195842318194312,"score_spread":0.20879868162208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}