{"id":"W3102505760","doi":"10.1182/blood-2020-138752","title":"The BET Inhibitor, CPI-0610, Promotes Myeloid Differentiation in Myelofibrosis Patient Bone Marrow and Peripheral CD34+ Hematopoietic Stem Cells","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Myelofibrosis; CD34; Haematopoiesis; Bone marrow; Stem cell; Medicine; Myeloid; Cancer research; Immunology; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003621876,0.0001861649,0.0003444824,0.0002196838,0.0001451947,0.0003181424,0.0001840031,0.0001496324,0.001537159],"category_scores_gemma":[0.00030206,0.000127731,0.0001261675,0.0001783368,0.00009765224,0.000139984,0.0001257154,0.0005096843,0.0003708987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002483707,"about_ca_system_score_gemma":0.000251755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005151049,"about_ca_topic_score_gemma":0.001754968,"domain_scores_codex":[0.9998904,0.00003264996,0.000008264267,0.00001485241,0.00003043026,0.00002346848],"domain_scores_gemma":[0.9999111,0.00001531865,0.00001714896,0.00000893241,0.00001117555,0.00003625798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01854793,0.004506768,0.03556341,0.0002979184,0.0001243065,0.0009192561,0.000192967,0.00179148,0.7366301,0.0003389134,0.006019953,0.1950669],"study_design_scores_gemma":[0.008387596,0.07725161,0.4475515,0.0001147707,0.0003442973,0.009614368,0.0002515445,0.01229187,0.4162786,0.0003860967,0.02747052,0.00005722185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965253,0.001275724,0.0001874735,0.00006103033,0.00001125389,0.0000523709,0.0002658207,0.0000369769,0.001583946],"genre_scores_gemma":[0.9969221,0.0004868965,0.0005722305,0.0000854558,0.00001014511,0.00004026407,0.0009993197,0.000006154519,0.0008773871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537159,"threshold_uncertainty_score":0.005142331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01121867932302201,"score_gpt":0.2097273345421328,"score_spread":0.1985086552191108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}