{"id":"W3102523565","doi":"10.1080/19420862.2020.1844928","title":"Impact of Fc N-linked glycans on in vivo clearance of an immunoglobulin G1 antibody produced by NS0 cell line","year":2020,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"AstraZeneca","keywords":"Glycan; Immunogenicity; Monoclonal antibody; Antibody; Glycosylation; In vivo; Chemistry; Fragment crystallizable region; Immunoglobulin G; Biochemistry; Immune system; Molecular biology; Biology; Immunology; Receptor; Glycoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002541637,0.0002529839,0.0002129535,0.0001007928,0.0001077589,0.0002650286,0.0001303247,0.0001751926,0.0005024754],"category_scores_gemma":[0.0003393921,0.00008245894,0.0001621446,0.00008537125,0.0001124512,0.0001242068,0.00009090229,0.0003283294,0.0001454957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002813755,"about_ca_system_score_gemma":0.0002011401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132581,"about_ca_topic_score_gemma":0.0009697977,"domain_scores_codex":[0.9997941,0.00008133322,0.00001295814,0.00002325263,0.00004252671,0.00004576836],"domain_scores_gemma":[0.9998323,0.00005501014,0.00003312685,0.00002734549,0.00002824414,0.0000239192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006140631,0.0001390836,0.001087074,0.00001573517,0.00001112551,0.00004121312,0.0000186426,0.0001781489,0.995809,0.00002448575,0.00003549464,0.002025945],"study_design_scores_gemma":[0.00002524681,0.001785303,0.01393015,0.000002672974,0.00002151359,0.0001637302,0.00001360255,0.001816627,0.981701,0.00001427641,0.000522359,0.000003417638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990267,0.0002671148,0.0003879748,0.00001949264,0.000005195299,0.000006947281,0.00006073727,0.0000105225,0.0002153109],"genre_scores_gemma":[0.9984342,0.0001542708,0.0004471054,0.00003386992,0.000004200955,0.000008549279,0.0003471428,0.000007680498,0.0005630134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00132581,"threshold_uncertainty_score":0.002636135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02843821252073137,"score_gpt":0.3566517964055766,"score_spread":0.3282135838848453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}