{"id":"W3102523565","doi":"10.1080/19420862.2020.1844928","title":"Impact of Fc N-linked glycans on in vivo clearance of an immunoglobulin G1 antibody produced by NS0 cell line","year":2020,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"AstraZeneca","keywords":"Glycan; Immunogenicity; Monoclonal antibody; Antibody; Glycosylation; In vivo; Chemistry; Fragment crystallizable region; Immunoglobulin G; Biochemistry; Immune system; Molecular biology; Biology; Immunology; Receptor; Glycoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001837437,0.0001758763,0.000502168,0.00009157113,0.00002435607,0.00000609186,0.0001992933,0.00008779508,0.0004639855],"category_scores_gemma":[0.0001032188,0.0001334716,0.0001538337,0.000395815,0.0001066924,0.00005459429,0.00005694188,0.0003278397,0.00004726795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003930395,"about_ca_system_score_gemma":0.0001391706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001259459,"about_ca_topic_score_gemma":0.00001356566,"domain_scores_codex":[0.9984425,0.00007679287,0.0004285549,0.0003178926,0.0004280574,0.0003061715],"domain_scores_gemma":[0.9992036,0.00005447102,0.0001147449,0.0003044968,0.0001277094,0.0001950271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009163903,0.000841899,0.02019743,0.0003809974,0.00004833833,0.00005347985,0.0004166058,0.00009198052,0.9660622,0.00002746684,0.001361385,0.001354298],"study_design_scores_gemma":[0.004723201,0.01376996,0.2455786,0.0003338013,0.00003244804,0.00001056915,0.00009795714,0.00381876,0.7272478,0.00002010056,0.004091693,0.0002750591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948748,0.0005726519,0.000005949709,0.002475523,0.00003407673,0.0003988892,0.0002364841,0.00001958562,0.00138205],"genre_scores_gemma":[0.9983989,0.0002656707,0.0001313131,0.0002303002,0.0001300469,0.000004569852,0.0001014129,0.00002424505,0.0007135353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2388144,"threshold_uncertainty_score":0.5442814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02843821252073137,"score_gpt":0.3566517964055766,"score_spread":0.3282135838848453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}