{"id":"W3102587288","doi":"10.3390/molecules25225235","title":"Circulating Ligands of the Receptor for Advanced Glycation End Products and the Soluble Form of the Receptor Modulate Cardiovascular Cell Apoptosis in Diabetes","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Glycation; Rage (emotion); Internal medicine; Endocrinology; Receptor; Apoptosis; Inflammation; Medicine; Advanced glycation end-product; Diabetes mellitus; Fas ligand; Type 2 diabetes; Immunology; Chemistry; Programmed cell death; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001549295,0.0001641091,0.0002521716,0.0002038188,0.00006668968,0.0002004434,0.00006896428,0.0001680465,0.0005894259],"category_scores_gemma":[0.0001973389,0.00009888495,0.0001395614,0.0001355311,0.00009753062,0.0001358192,0.0001351369,0.0003082625,0.0001104789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009051641,"about_ca_system_score_gemma":0.00004733542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000150074,"about_ca_topic_score_gemma":0.0002207444,"domain_scores_codex":[0.9999058,0.00003165647,0.000006599742,0.00002076387,0.0000161712,0.00001896531],"domain_scores_gemma":[0.9998918,0.00001611356,0.00003552855,0.000009559662,0.00001310863,0.00003396734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01365474,0.0007147562,0.1642998,0.0001805438,0.0001600143,0.0005485329,0.0003296864,0.0002245325,0.7892336,0.0001102712,0.000254111,0.03028945],"study_design_scores_gemma":[0.0003336032,0.009053772,0.9292161,0.00002340458,0.0001600994,0.00144008,0.0003145486,0.001053541,0.05628571,0.0002103275,0.001892594,0.0000160995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979122,0.001692067,0.0001467595,0.00001747597,0.00000962696,0.000004129695,0.00003078404,0.000002595167,0.0001843602],"genre_scores_gemma":[0.9985688,0.0007398963,0.0002169716,0.00003280117,0.00002101051,0.000009987242,0.00007712801,0.000001034018,0.0003321912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005894259,"threshold_uncertainty_score":0.001971841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149417408792668,"score_gpt":0.227745447664784,"score_spread":0.2162512735768573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}