{"id":"W3102888846","doi":"10.1038/s41419-020-03168-4","title":"Stroma secreted IL6 selects for “stem-like” population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways","year":2020,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Welichem Biotech (Canada)","funders":"Office of Extramural Research, National Institutes of Health; Florida Department of Health; Sylvester Comprehensive Cancer Center, University of Miami Health Systems; University of Miami; Pancreatic Cancer Action Network; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Tumor microenvironment; Pancreatic cancer; Stromal cell; Stroma; Cancer research; Biology; Population; Pancreatic tumor; Cytokine; Reprogramming; Immune system; Cancer; Immunology; Medicine; Cell; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005520129,0.0001539439,0.000112283,0.000100371,0.00006198036,0.0002069037,0.00006112077,0.0001125467,0.001111894],"category_scores_gemma":[0.00004880456,0.00004408405,0.0001445209,0.00007230852,0.00008626957,0.0001073721,0.0001119583,0.0003446939,0.0001821037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007069184,"about_ca_system_score_gemma":0.000100135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001058348,"about_ca_topic_score_gemma":0.0001815609,"domain_scores_codex":[0.999944,0.0000105354,0.00000482929,0.00001155979,0.00001462691,0.00001437272],"domain_scores_gemma":[0.9999571,0.000006367588,0.00001330531,0.00000450043,0.000004142315,0.00001456708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008739789,0.00001848128,0.0004908378,0.00002097129,0.000002040201,0.00004814414,0.00001036901,0.00005766123,0.9978108,0.0000501656,0.0000311521,0.001371935],"study_design_scores_gemma":[0.00002128575,0.0003300355,0.007043232,0.000006368958,0.00001659169,0.00041217,0.00006612839,0.00120665,0.9866983,0.0000774006,0.004118194,0.000003664102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941095,0.001041279,0.003217462,0.0001148391,0.00003293774,0.00001802228,0.000230506,0.00007073407,0.001164715],"genre_scores_gemma":[0.9958376,0.0007282145,0.001803701,0.0000796929,0.00001372745,0.00001948193,0.00025552,0.00001601827,0.001246068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111894,"threshold_uncertainty_score":0.003719687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02470500121604689,"score_gpt":0.2634303398009052,"score_spread":0.2387253385848583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}