{"id":"W3103162811","doi":"10.1101/2020.11.11.378240","title":"The Palmitoyl Acyltransferase ZDHHC14 Controls Kv1-Family Potassium Channel Clustering at the Axon Initial Segment","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Waterloo; Shriners Hospitals for Children; Temple University; Johns Hopkins University","keywords":"PDZ domain; Palmitoylation; Guanylate kinase; Potassium channel; Axon; Cell biology; Biology; Neurexin; Hippocampal formation; Neuroscience; Chemistry; Biochemistry; Biophysics; Membrane protein; Enzyme; Receptor; Postsynaptic potential","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299236,0.0002721053,0.0002578635,0.0003384232,0.0003405378,0.0004583026,0.0004100577,0.0003208475,0.001668346],"category_scores_gemma":[0.0001887906,0.0002429352,0.0002399672,0.0002536671,0.0004927898,0.0002040167,0.0004792835,0.0004277687,0.0009291902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001007135,"about_ca_system_score_gemma":0.000448922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002150752,"about_ca_topic_score_gemma":0.003913108,"domain_scores_codex":[0.999759,0.00002178113,0.00002722351,0.00006227198,0.00006517173,0.00006451297],"domain_scores_gemma":[0.9997429,0.00002725279,0.00009757338,0.00003789092,0.00004106431,0.0000532179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001723448,0.00001919025,0.0004880364,0.00002151739,0.000005653508,0.00003848762,0.00001069447,0.0001024256,0.9979904,0.0001892818,0.00006058395,0.0009013309],"study_design_scores_gemma":[0.00001738352,0.00005392253,0.006853464,0.000003494628,0.000009274315,0.00006178924,0.00002687205,0.0009525711,0.9905462,0.00005538969,0.001416004,0.000003544945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940849,0.0005226359,0.002785164,0.0001250831,0.00003281259,0.00002034914,0.0007868907,0.0001268009,0.001515327],"genre_scores_gemma":[0.9925545,0.0003481707,0.002013582,0.00006687645,0.000006754114,0.00002398964,0.001009875,0.0001113051,0.003864966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002150752,"threshold_uncertainty_score":0.007307351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05291416935863896,"score_gpt":0.2928293183448379,"score_spread":0.239915148986199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}