{"id":"W3103239306","doi":"10.21203/rs.3.rs-100397/v1","title":"ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2 replication","year":2020,"lang":"en","type":"preprint","venue":"","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"School of Medicine, Shanghai Jiao Tong University; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning; Science and Technology Commission of Shanghai Municipality; Fudan University; National Natural Science Foundation of China; Shanghai Municipal Health Commission; Shanghai Jiao Tong University; Shandong University","keywords":"Replication (statistics); Autophagy; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Viral replication; Cell biology; Coronavirus disease 2019 (COVID-19); Computer science; Biology; Computational biology; Genetics; Medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001240819,0.0002663585,0.000298567,0.0001459371,0.0002249798,0.0003588435,0.0001587766,0.0003313588,0.003645441],"category_scores_gemma":[0.0001407873,0.00009264429,0.0005449145,0.0001296636,0.0001507211,0.0002398711,0.0002129288,0.0004930919,0.001220224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003437521,"about_ca_system_score_gemma":0.0003223391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008536165,"about_ca_topic_score_gemma":0.0009414079,"domain_scores_codex":[0.9998423,0.00002223108,0.00001819181,0.00002903281,0.00004233049,0.00004582441],"domain_scores_gemma":[0.9999036,0.00001381922,0.00002809881,0.00001270796,0.00001654776,0.00002523844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002401218,0.00004090961,0.0001805402,0.00003822246,0.000003813808,0.00005691031,0.000007085288,0.00003132314,0.9985635,0.00006604816,0.0001878253,0.000583779],"study_design_scores_gemma":[0.00002715621,0.000347395,0.009281742,0.00001242797,0.00002242376,0.0003400194,0.00004484583,0.001319285,0.9831151,0.0000579528,0.005422296,0.000009295662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924926,0.001413738,0.001671643,0.0002310611,0.0001539394,0.00003504627,0.001268256,0.0001659537,0.002567729],"genre_scores_gemma":[0.9910058,0.000669409,0.001546792,0.000168881,0.00002785855,0.00003982158,0.002016578,0.00005261926,0.004472287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003645441,"threshold_uncertainty_score":0.01219523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08465523447946215,"score_gpt":0.3550859498088766,"score_spread":0.2704307153294144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}