{"id":"W3103258656","doi":"10.2217/epi-2020-0034","title":"<i>CACNA1C</i> Methylation: Association with Cortisol, Perceived Stress, rs1006737 and Childhood Trauma in Males","year":2020,"lang":"en","type":"article","venue":"Epigenomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Medical Research Council","keywords":"DNA methylation; Methylation; Cortisol awakening response; Morning; CpG site; Biology; Genotyping; Pyrosequencing; Epigenetics; Clinical psychology; Internal medicine; Genetics; Hydrocortisone; Physiology; Psychology; Endocrinology; Genotype; Medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272791,0.0001448961,0.0001626061,0.00002768944,0.00006449207,0.00003934161,0.00008546981,0.0001528073,0.00001213811],"category_scores_gemma":[0.0000735164,0.0001441408,0.00003427835,0.00009489682,0.00002909483,0.000007311241,0.00004470242,0.0001113208,0.00000517837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003362554,"about_ca_system_score_gemma":0.00005173795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002788847,"about_ca_topic_score_gemma":0.0002005961,"domain_scores_codex":[0.9990603,0.00006800552,0.0002249884,0.0003362546,0.0001179927,0.0001924971],"domain_scores_gemma":[0.9995617,0.0000209889,0.0001337134,0.0001341088,0.00005320965,0.00009631601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000114147,0.0000787945,0.6576955,0.00002383672,0.00006731322,0.000004442829,0.001517039,0.002447268,0.3300767,0.00004010093,0.00003812588,0.007896796],"study_design_scores_gemma":[0.0009815542,0.0005013499,0.8671006,0.00001151485,0.00002774778,0.000001070862,0.0002074027,0.0003777099,0.1248836,0.00008128067,0.005550364,0.0002758024],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953283,0.001971619,0.001229106,0.0006004152,0.00003897071,0.0002038673,0.00003910558,0.00001149124,0.0005771078],"genre_scores_gemma":[0.9961961,0.001392436,0.001672709,0.0002408365,0.0002061334,0.00000942673,0.0001861366,0.00002654084,0.0000696602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2094052,"threshold_uncertainty_score":0.5877893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008688128926727112,"score_gpt":0.2137711626005981,"score_spread":0.205083033673871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}