{"id":"W3103271459","doi":"10.1016/j.bbi.2020.11.008","title":"Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression","year":2020,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":258,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Neuroinflammation; Ibrutinib; SNAP25; Inflammasome; Proinflammatory cytokine; Pharmacology; Neuroscience; Medicine; Immunology; Psychology; Inflammation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002111652,0.0009006899,0.000654279,0.0005615505,0.0002781216,0.0003665392,0.0005503529,0.0006648822,0.001390516],"category_scores_gemma":[0.0001465148,0.0002700532,0.0004422425,0.00025376,0.0004123171,0.0002845703,0.0001776669,0.0016674,0.0004404104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004669485,"about_ca_system_score_gemma":0.0003639777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001399595,"about_ca_topic_score_gemma":0.002504188,"domain_scores_codex":[0.9998384,0.00002527454,0.00001836983,0.00002316437,0.00003146445,0.00006339558],"domain_scores_gemma":[0.9998977,0.000004929019,0.00003273072,0.000008716384,0.000007786091,0.00004805675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0038829,0.0005657769,0.000324117,0.0001537724,0.00005827359,0.0002839331,0.00002529763,0.0002939875,0.987222,0.0001685288,0.000549413,0.006471871],"study_design_scores_gemma":[0.003366966,0.01087831,0.0196867,0.0001271533,0.0005623658,0.002357669,0.0002573054,0.004641735,0.94713,0.0005217122,0.01039861,0.00007139131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908949,0.003291368,0.001614677,0.0006907075,0.0001954173,0.00006628171,0.0008330729,0.0004128716,0.002000824],"genre_scores_gemma":[0.992486,0.002389977,0.001278693,0.0001907112,0.00005292349,0.00009056539,0.0006835904,0.00003875837,0.002788928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399595,"threshold_uncertainty_score":0.004651725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05665492713635675,"score_gpt":0.2740969959075504,"score_spread":0.2174420687711936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}