{"id":"W3103271459","doi":"10.1016/j.bbi.2020.11.008","title":"Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression","year":2020,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":258,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Neuroinflammation; Ibrutinib; SNAP25; Inflammasome; Proinflammatory cytokine; Pharmacology; Neuroscience; Medicine; Immunology; Psychology; Inflammation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081368,0.0001264527,0.0001772472,0.00006898869,0.00007531758,0.00002878955,0.0001281515,0.00007045217,0.0000126146],"category_scores_gemma":[0.000513853,0.0001201661,0.00003081117,0.0001439511,0.00007477405,0.0001984275,0.0001394708,0.000198695,0.000002279615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005643154,"about_ca_system_score_gemma":0.00001947363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004826006,"about_ca_topic_score_gemma":0.000014256,"domain_scores_codex":[0.9990808,0.0001763521,0.0002113586,0.0002544143,0.0001194644,0.0001575523],"domain_scores_gemma":[0.9994674,0.0001943881,0.00007953445,0.0001607256,0.0000123231,0.00008561109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006025586,0.00008182241,0.01192477,0.00004426525,7.733049e-7,0.000002611748,0.001038932,0.00003470689,0.9844011,0.00008052067,0.000005328995,0.002324912],"study_design_scores_gemma":[0.001339718,0.000180754,0.1454322,0.00002968499,0.000008475658,0.000004996661,0.0002583034,0.01254693,0.8398972,0.0001209506,0.000003968143,0.0001768081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992033,0.00004849349,0.00001641435,0.0001947611,0.00001431242,0.000350157,0.00001035644,0.00004384367,0.0001183455],"genre_scores_gemma":[0.99954,0.00005018721,0.00005345192,0.0003011762,0.000003597951,0.00001581467,0.000002950408,0.00001343426,0.00001940711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1445039,"threshold_uncertainty_score":0.490023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05665492713635675,"score_gpt":0.2740969959075504,"score_spread":0.2174420687711936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}