{"id":"W3103340171","doi":"10.1172/jci.insight.142740","title":"Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; U.S. Department of Defense","keywords":"Podocyte; Calpain; Knockout mouse; Kinase; Cell biology; Cyclin; Cancer research; Chemistry; Internal medicine; Medicine; Biology; Apoptosis; Biochemistry; Kidney; Enzyme; Cell cycle; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147743,0.0001257304,0.0001326192,0.00004282504,0.00006271736,0.00002528758,0.00005001234,0.0001855563,0.00002340929],"category_scores_gemma":[0.0003776886,0.0001217965,0.00004774786,0.0001539484,0.00006046687,0.000006382911,0.0000778362,0.0001282634,0.000009430323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002021326,"about_ca_system_score_gemma":0.00003689483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002673224,"about_ca_topic_score_gemma":0.00005936959,"domain_scores_codex":[0.9990993,0.0001172775,0.0002233142,0.0003022497,0.00009171144,0.000166171],"domain_scores_gemma":[0.9996732,0.00001956876,0.00007748681,0.000080855,0.00004170346,0.0001072254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001461845,0.00004511992,0.004565259,0.00002331867,0.00002048305,0.000008834252,0.0002665746,0.00003539422,0.9902966,0.00003031209,0.002140135,0.002421773],"study_design_scores_gemma":[0.001388114,0.0002835527,0.01666469,0.00007261086,0.00001781597,0.000005197976,0.0002397385,0.002120125,0.910516,0.00008552279,0.06823091,0.0003756784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967859,0.0006199651,0.0001410619,0.00143899,0.00007126402,0.0001780616,0.00001492577,0.00002776457,0.0007221146],"genre_scores_gemma":[0.9969648,0.00006923648,0.0001121162,0.002136643,0.0002069376,0.00001342701,0.0001723085,0.00001780394,0.0003066894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07978056,"threshold_uncertainty_score":0.4966716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007016864981028,"score_gpt":0.2258720687186782,"score_spread":0.2158019000688679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}