{"id":"W3103454309","doi":"10.1021/acs.bioconjchem.0c00590","title":"DiPODS: A Reagent for Site-Specific Bioconjugation via the Irreversible Rebridging of Disulfide Linkages","year":2020,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Bioconjugation; Chemistry; Reagent; Bifunctional; Maleimide; Combinatorial chemistry; Covalent bond; Conjugated system; Thiol; Amine gas treating; Cysteine; Organic chemistry; Catalysis; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002258534,0.0001886804,0.0003148572,0.00002175757,0.0001485917,0.00002606056,0.0002055744,0.0001061583,0.0003679323],"category_scores_gemma":[0.0001921707,0.0001308235,0.0002413159,0.0002048199,0.0002167351,0.00003901197,0.000112908,0.000222506,0.00003986158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003816009,"about_ca_system_score_gemma":0.00009365859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003665583,"about_ca_topic_score_gemma":6.087312e-7,"domain_scores_codex":[0.9985976,0.00002181858,0.0003966832,0.0003616361,0.0003171621,0.0003050992],"domain_scores_gemma":[0.9989133,0.0001777172,0.0001499939,0.0003025112,0.0001798112,0.0002766508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004793099,0.00006843094,0.002676519,0.001083991,0.00008240982,0.00001059424,0.0003605824,0.00000349486,0.9830997,0.00004841926,0.009692104,0.002394465],"study_design_scores_gemma":[0.0008810323,0.0001403946,0.001119494,0.0001237152,0.00005607326,0.00001880452,0.000219208,0.0008755142,0.8634969,0.00008085211,0.1328419,0.0001461141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727305,0.002289484,0.0006834982,0.02067529,0.00006740622,0.0008844761,0.00018977,0.00006299274,0.002416622],"genre_scores_gemma":[0.9939846,0.0006033712,0.0009502447,0.0008910167,0.0007772377,0.00006673706,0.0003047646,0.00003134013,0.002390716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1231498,"threshold_uncertainty_score":0.5334828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760084559139872,"score_gpt":0.2885232299183714,"score_spread":0.2409223843269727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}