{"id":"W3103454309","doi":"10.1021/acs.bioconjchem.0c00590","title":"DiPODS: A Reagent for Site-Specific Bioconjugation via the Irreversible Rebridging of Disulfide Linkages","year":2020,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Bioconjugation; Chemistry; Reagent; Bifunctional; Maleimide; Combinatorial chemistry; Covalent bond; Conjugated system; Thiol; Amine gas treating; Cysteine; Organic chemistry; Catalysis; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002851931,0.0005273724,0.0002465046,0.0003170889,0.0001608426,0.0003352913,0.0005015478,0.0003838953,0.000782117],"category_scores_gemma":[0.0001720663,0.000320156,0.0001621939,0.0001823863,0.0002908089,0.0003282414,0.0002453903,0.0007562379,0.0003901924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004242969,"about_ca_system_score_gemma":0.0002460796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003276015,"about_ca_topic_score_gemma":0.0004177755,"domain_scores_codex":[0.9998281,0.00002303432,0.00001586977,0.00004852104,0.00006400522,0.00002045605],"domain_scores_gemma":[0.999916,0.0000189389,0.00002434947,0.00001196817,0.00001316971,0.0000157124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002565473,0.00001056186,0.00005249685,0.0001334298,0.000006715657,0.00004519013,0.00001618205,0.0001003072,0.9934536,0.0004485682,0.0001867884,0.005520455],"study_design_scores_gemma":[0.000008307809,0.00006169004,0.0001306318,0.000002633345,0.000005209684,0.0001911673,0.000003199917,0.000566761,0.9926913,0.00006217674,0.006271647,0.000005205324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5654082,0.01697282,0.4036095,0.0007814013,0.0004724929,0.000516851,0.001605836,0.002949,0.007683872],"genre_scores_gemma":[0.7869167,0.00708122,0.1929302,0.0003235663,0.00006900624,0.0002073439,0.00115141,0.0001910892,0.01112944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000782117,"threshold_uncertainty_score":0.00307852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760084559139872,"score_gpt":0.2885232299183714,"score_spread":0.2409223843269727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}