{"id":"W3103690900","doi":"10.1161/circ.142.suppl_3.14267","title":"Abstract 14267: Evinacumab Lowers LDL-C in Patients With Homozygous Familial Hypercholesterolemia Irrespective of Background Lipid-lowering Medication","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; Ezetimibe; PCSK9; Familial hypercholesterolemia; Placebo; Internal medicine; Statin; Alirocumab; Clinical endpoint; Gastroenterology; Randomized controlled trial; Cholesterol; Lipoprotein; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000920868,0.000580024,0.001793365,0.0002380339,0.0002726712,0.0005081362,0.0003164659,0.0009701767,0.004672907],"category_scores_gemma":[0.0007602636,0.0003086975,0.0007713182,0.0002089182,0.0003889268,0.000378705,0.0002042485,0.001143875,0.0006011589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002609208,"about_ca_system_score_gemma":0.0005390574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004185109,"about_ca_topic_score_gemma":0.001204746,"domain_scores_codex":[0.9996892,0.0001530688,0.00002948361,0.00004416881,0.00003173554,0.00005243471],"domain_scores_gemma":[0.9996252,0.00009465848,0.00009519831,0.00002258255,0.00003101919,0.0001312794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8803077,0.009953878,0.00869486,0.001515117,0.002029348,0.0001573867,0.0001075629,0.0003733695,0.02413505,0.0001619544,0.003023088,0.06954075],"study_design_scores_gemma":[0.7635382,0.1826815,0.04422,0.0002337316,0.001707951,0.0003265961,0.00006746263,0.0008396585,0.003401382,0.0001708774,0.002777853,0.00003476078],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896905,0.006726949,0.0002107579,0.0003862873,0.0001534231,0.0004592738,0.000355436,0.0000626615,0.001954723],"genre_scores_gemma":[0.9952263,0.001622776,0.0006166992,0.0005796686,0.0002165881,0.0003591614,0.0004041175,0.000008512835,0.000966175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004672907,"threshold_uncertainty_score":0.01563245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850158133759616,"score_gpt":0.2496361528364842,"score_spread":0.2311345714988881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}