{"id":"W3103697444","doi":"10.3390/ijns6040091","title":"Newborn Screening for Mucopolysaccharidosis I: Moving Forward Learning from Experience","year":2020,"lang":"en","type":"article","venue":"International Journal of Neonatal Screening","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Newborn screening; Mucopolysaccharidosis; Medicine; Biomarker; Enzyme replacement therapy; Pediatrics; Disease; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002611541,0.0001945337,0.0003914061,0.0002169727,0.000137519,0.0001392185,0.0006329904,0.00009386621,0.0005604376],"category_scores_gemma":[0.002109748,0.0001816852,0.0003842142,0.0002156744,0.00007169871,0.0006390624,0.0002336766,0.0006460213,0.00001165406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000858213,"about_ca_system_score_gemma":0.0001133113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002242213,"about_ca_topic_score_gemma":0.000006231576,"domain_scores_codex":[0.9973093,0.00004934815,0.0006470296,0.0002974831,0.001364649,0.0003321822],"domain_scores_gemma":[0.9977702,0.00036328,0.0004344505,0.00009613287,0.0009141929,0.0004217156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003505104,0.00004354694,0.04942879,0.00002027174,0.0006428355,0.000624894,0.003878595,0.002274962,0.02178284,0.00002681492,0.0005748499,0.9171965],"study_design_scores_gemma":[0.02121338,0.003297219,0.04068086,0.001870213,0.0003838976,0.001287656,0.02880088,0.2809927,0.03969707,0.0003694616,0.5803039,0.001102789],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1820965,0.0007558832,0.8103586,0.006192991,0.0002267357,0.0001824861,0.00002259659,0.00003828405,0.000125916],"genre_scores_gemma":[0.7368487,0.00005613682,0.2604626,0.001059216,0.001405216,0.000009213076,0.00003910921,0.0000413239,0.00007848713],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.9160937,"threshold_uncertainty_score":0.7408906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06334219266723634,"score_gpt":0.3413471169501007,"score_spread":0.2780049242828643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}