{"id":"W3103707491","doi":"10.1021/acsbiomaterials.0c01306","title":"Self-Assembled, Dilution-Responsive Hydrogels for Enhanced Thermal Stability of Insulin Biopharmaceuticals","year":2020,"lang":"en","type":"article","venue":"ACS Biomaterials Science & Engineering","topic":"Hydrogels: synthesis, properties, applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; Danmarks Frie Forskningsfond; Novo Nordisk; Natural Sciences and Engineering Research Council of Canada; Stanford University; Bill and Melinda Gates Foundation; California Institute of Technology; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense; National Science Foundation","keywords":"Self-healing hydrogels; Insulin; Excipient; Dilution; Poloxamer; Supramolecular chemistry; Chemistry; Nanotechnology; Materials science; Polymer; Chromatography; Organic chemistry; Medicine; Molecule; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385834,0.0002312768,0.0001106026,0.0001417931,0.00007805667,0.0001609228,0.0001481807,0.0001633924,0.0007724807],"category_scores_gemma":[0.0001141506,0.00009638361,0.0001211822,0.00008012696,0.00009367673,0.0002458659,0.0001443448,0.0003451713,0.0001971816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002017684,"about_ca_system_score_gemma":0.00009633804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001369179,"about_ca_topic_score_gemma":0.0003661956,"domain_scores_codex":[0.9999202,0.000008373825,0.000008207546,0.00001979646,0.00002778823,0.00001561393],"domain_scores_gemma":[0.9999392,0.00001274891,0.00002177783,0.000004636958,0.000008506007,0.00001309938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001209621,0.00001109517,0.00001691136,0.0000151566,0.000001021079,0.0000110731,0.000005951269,0.00007483143,0.998988,0.00004378341,0.00001837477,0.000801618],"study_design_scores_gemma":[0.000005346769,0.0000575568,0.0001468698,0.000001295219,0.000002397528,0.00002507074,0.000002335576,0.0008839,0.9983221,0.00001138709,0.000539283,0.000002461573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677356,0.002722121,0.0254063,0.0001369542,0.00008565014,0.000108778,0.0003148809,0.0003683484,0.003121434],"genre_scores_gemma":[0.9841791,0.0006133065,0.01287765,0.00007251006,0.00001706623,0.00004978556,0.0001043977,0.00003474197,0.002051536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007724807,"threshold_uncertainty_score":0.002584219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02524163127625252,"score_gpt":0.273632891206935,"score_spread":0.2483912599306824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}