{"id":"W3103707491","doi":"10.1021/acsbiomaterials.0c01306","title":"Self-Assembled, Dilution-Responsive Hydrogels for Enhanced Thermal Stability of Insulin Biopharmaceuticals","year":2020,"lang":"en","type":"article","venue":"ACS Biomaterials Science & Engineering","topic":"Hydrogels: synthesis, properties, applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; Danmarks Frie Forskningsfond; Novo Nordisk; Natural Sciences and Engineering Research Council of Canada; Stanford University; Bill and Melinda Gates Foundation; California Institute of Technology; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense; National Science Foundation","keywords":"Self-healing hydrogels; Insulin; Excipient; Dilution; Poloxamer; Supramolecular chemistry; Chemistry; Nanotechnology; Materials science; Polymer; Chromatography; Organic chemistry; Medicine; Molecule; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006649356,0.0001939642,0.0002498415,0.00006172381,0.000114704,0.0000489526,0.0005363949,0.000103972,0.00001332228],"category_scores_gemma":[0.0007092108,0.0001800988,0.00007406899,0.0003539426,0.0001373742,0.00002692236,0.0002064258,0.00002506604,0.00001105764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003746728,"about_ca_system_score_gemma":0.0002093949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007790267,"about_ca_topic_score_gemma":4.645362e-7,"domain_scores_codex":[0.9984219,0.00003882856,0.0004170416,0.0005206698,0.0002050642,0.0003964984],"domain_scores_gemma":[0.999083,0.00004079329,0.0001191013,0.0003745133,0.0001999984,0.000182541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000086295,0.0000443817,0.00002487584,0.00006345265,0.00002446756,1.957868e-7,0.0002084355,0.0003793011,0.9987648,0.0001154317,0.00000211619,0.0002862324],"study_design_scores_gemma":[0.0002916896,0.0001263212,0.0001979236,0.00001116006,0.00002157791,0.000001547972,0.00003285987,0.001366962,0.9957743,0.000005200975,0.001964069,0.0002063545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882597,0.0002919612,0.01028516,0.0002196976,0.0001235287,0.0006510497,0.00006918537,0.00007937636,0.00002031746],"genre_scores_gemma":[0.9922442,0.0000490962,0.00724239,0.00008817085,0.000133206,0.0002041587,0.0000117695,0.00002623678,7.963367e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003984453,"threshold_uncertainty_score":0.7344216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02524163127625252,"score_gpt":0.273632891206935,"score_spread":0.2483912599306824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}