{"id":"W3103787729","doi":"10.3390/ijms21228721","title":"Mechanistic Insights into Synergy between Melanin-Targeting Radioimmunotherapy and Immunotherapy in Experimental Melanoma","year":2020,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Melanoma; Radioimmunotherapy; Medicine; Immunotherapy; Tumor microenvironment; Immune checkpoint; Cancer research; Melanin; Combination therapy; Blockade; Oncology; Cancer; Pharmacology; Internal medicine; Antibody; Immunology; Monoclonal antibody; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004082211,0.0004598447,0.0003430931,0.0002611823,0.000131256,0.0004132492,0.0004203562,0.0005265737,0.002251963],"category_scores_gemma":[0.0001220496,0.0001958007,0.0004801704,0.0001019401,0.0003212628,0.000401031,0.0002110124,0.0007259802,0.0002948807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000367444,"about_ca_system_score_gemma":0.0002013608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002481863,"about_ca_topic_score_gemma":0.0003709401,"domain_scores_codex":[0.9998633,0.0000453086,0.000007387966,0.00001956057,0.00002179481,0.00004266664],"domain_scores_gemma":[0.999921,0.00002145345,0.00002671601,0.000009554855,0.000004133866,0.00001717293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007669847,0.0003696852,0.000378308,0.000307851,0.00003647663,0.0003212086,0.00002324157,0.0008683561,0.989639,0.003006497,0.0001496451,0.004132828],"study_design_scores_gemma":[0.0004926286,0.006873677,0.01225528,0.000154087,0.0001574426,0.002346775,0.0001339398,0.01017579,0.9511116,0.004612687,0.0116565,0.00002962935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9518514,0.01974351,0.01539443,0.0020028,0.0001287096,0.0003706178,0.0003916526,0.0001987661,0.009918124],"genre_scores_gemma":[0.9876581,0.005776651,0.004111407,0.0003849316,0.00005310214,0.0001037519,0.0001655103,0.00001775068,0.001728709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002251963,"threshold_uncertainty_score":0.00753355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02367979991631527,"score_gpt":0.3329146634146059,"score_spread":0.3092348634982907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}