{"id":"W3103802728","doi":"10.1186/s13395-020-00243-4","title":"Ryanodine receptor 1-related disorders: an historical perspective and proposal for a unified nomenclature","year":2020,"lang":"en","type":"review","venue":"Skeletal Muscle","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"NHLBI Division of Intramural Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Nursing Research; Menzies Centre for Australian Studies, King's College London, University of London; European Neuromuscular Centre; King's College London; National Institutes of Health; Cure CMD; RYR-1 Foundation; Muscular Dystrophy Association","keywords":"RYR1; Malignant hyperthermia; Central core disease; Ryanodine receptor; Congenital myopathy; Myopathy; Pathology; Biology; Medicine; Internal medicine; Muscle biopsy; Biopsy; Calcium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007473914,0.001598313,0.00289196,0.008545199,0.002319566,0.004504916,0.003425399,0.004571442,0.001824304],"category_scores_gemma":[0.007541967,0.0004405775,0.001102777,0.006024167,0.01019036,0.009518933,0.004068065,0.01007879,0.001161864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003631162,"about_ca_system_score_gemma":0.004327656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002564505,"about_ca_topic_score_gemma":0.002072529,"domain_scores_codex":[0.9973297,0.0009369669,0.000592856,0.0005364309,0.0003634599,0.0002405705],"domain_scores_gemma":[0.9945939,0.002866042,0.0004767871,0.0002123679,0.001314468,0.0005364702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003659636,0.0002377719,0.003933154,0.004376145,0.0001410186,0.004731158,0.006101924,0.0008706966,0.001543196,0.3908076,0.1784569,0.4084345],"study_design_scores_gemma":[0.00004156835,0.0002056273,0.001653807,0.003285196,0.00006289846,0.01163161,0.001770765,0.0004494061,0.0002018537,0.07139999,0.9091945,0.0001028607],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002103446,0.9119841,0.006288421,0.05464169,0.01889341,0.00003387877,0.0001015701,0.00008070712,0.005872747],"genre_scores_gemma":[0.02361163,0.8720669,0.01416705,0.02928517,0.05723197,0.0001994709,0.0003758377,0.00008905066,0.002972934],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008545199,"threshold_uncertainty_score":0.03952634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762974049379861,"score_gpt":0.2817722089473196,"score_spread":0.264142468453521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}