{"id":"W3103813357","doi":"10.3389/fnbeh.2020.578443","title":"Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse","year":2020,"lang":"en","type":"article","venue":"Frontiers in Behavioral Neuroscience","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Parkinsonfonden; Stiftelsen Zoologisk Forskning; Hjärnfonden; Bertil Hållstens Forskningsstiftelse; O. E. och Edla Johanssons Vetenskapliga Stiftelse; Uppsala Universitet; Vetenskapsrådet; Åhlén-stiftelsen; McGill University","keywords":"Monoaminergic; Monoamine neurotransmitter; Neuroscience; Dopamine; Galanin; Biology; Conditional gene knockout; Vesicular monoamine transporter 2; Neurochemical; Dopamine transporter; Calbindin; Serotonin; Vesicular monoamine transporter; Dopaminergic; Neuropeptide; Genetics; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005950909,0.0004339828,0.0007100169,0.000868156,0.00007116879,0.00004135934,0.0011242,0.0001525099,0.000002705484],"category_scores_gemma":[0.0004039577,0.0004044938,0.00009078128,0.004149118,0.00091102,0.0004365535,0.0001631193,0.0008453241,9.679933e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845436,"about_ca_system_score_gemma":0.0001604033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002555264,"about_ca_topic_score_gemma":0.0002776089,"domain_scores_codex":[0.994825,0.0009528157,0.001099816,0.00151027,0.0008183633,0.000793728],"domain_scores_gemma":[0.9987215,0.0001471908,0.0003159817,0.0005233331,0.00005233621,0.0002396721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001316545,0.0004779787,0.3198806,0.00001431364,1.743155e-7,0.0002686187,0.01247794,0.000145542,0.6646051,0.000001206142,0.000009534898,0.0008024144],"study_design_scores_gemma":[0.001250271,0.0005992441,0.5498775,0.00009511512,0.00001110036,0.000009230988,0.000237511,0.0001334995,0.4475571,0.000002039835,0.00001779913,0.0002096164],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950545,0.00002077933,0.00002127828,0.001353882,0.000470713,0.002674134,0.0003704321,0.00002746711,0.000006755969],"genre_scores_gemma":[0.9982676,0.00003474675,0.0003498021,0.0009592236,0.000008527726,0.0003039555,0.000001827933,0.00004697413,0.00002733943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2299968,"threshold_uncertainty_score":0.9998407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0301803990506135,"score_gpt":0.2827072821340841,"score_spread":0.2525268830834706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}