{"id":"W3103813357","doi":"10.3389/fnbeh.2020.578443","title":"Selective Knockout of the Vesicular Monoamine Transporter 2 (Vmat2) Gene in Calbindin2/Calretinin-Positive Neurons Results in Profound Changes in Behavior and Response to Drugs of Abuse","year":2020,"lang":"en","type":"article","venue":"Frontiers in Behavioral Neuroscience","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Parkinsonfonden; Stiftelsen Zoologisk Forskning; Hjärnfonden; Bertil Hållstens Forskningsstiftelse; O. E. och Edla Johanssons Vetenskapliga Stiftelse; Uppsala Universitet; Vetenskapsrådet; Åhlén-stiftelsen; McGill University","keywords":"Monoaminergic; Monoamine neurotransmitter; Neuroscience; Dopamine; Galanin; Biology; Conditional gene knockout; Vesicular monoamine transporter 2; Neurochemical; Dopamine transporter; Calbindin; Serotonin; Vesicular monoamine transporter; Dopaminergic; Neuropeptide; Genetics; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513391,0.0008222316,0.0006445853,0.0007773804,0.0003581057,0.0004994565,0.0005658185,0.000775244,0.00257057],"category_scores_gemma":[0.0001501498,0.000467858,0.0006358406,0.0003196443,0.0006388991,0.0003881039,0.000520688,0.001521984,0.0008091994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005630393,"about_ca_system_score_gemma":0.0003581328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001383536,"about_ca_topic_score_gemma":0.003458567,"domain_scores_codex":[0.9995894,0.00001878312,0.0000416336,0.0001468704,0.0001210706,0.00008226866],"domain_scores_gemma":[0.9997575,0.00001729568,0.00008350776,0.0000236421,0.00001862359,0.00009942616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005392628,0.00002472007,0.0001293069,0.0000188815,0.000006675867,0.0001107095,0.00001250398,0.00002845517,0.9988427,0.00009053253,0.00004220111,0.0006393586],"study_design_scores_gemma":[0.0000447167,0.0002280209,0.008930752,0.00001134286,0.00004794516,0.0010528,0.00004504882,0.0007357532,0.9858541,0.00006887655,0.00296715,0.00001357795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817762,0.001427439,0.01108635,0.0002771119,0.0001632429,0.0001368298,0.002385333,0.0005681891,0.002179366],"genre_scores_gemma":[0.9650092,0.00175771,0.01280077,0.000246651,0.00002972115,0.0002717699,0.002022048,0.0002958799,0.01756632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00257057,"threshold_uncertainty_score":0.008599401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0301803990506135,"score_gpt":0.2827072821340841,"score_spread":0.2525268830834706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}