{"id":"W3103917633","doi":"10.3390/cancers12113339","title":"Modulation of de Novo Lipogenesis Improves Response to Enzalutamide Treatment in Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; University of British Columbia; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Enzalutamide; Prostate cancer; Lipogenesis; Cancer research; LNCaP; Internal medicine; Cancer; Medicine; Cancer cell; Endocrinology; Oncology; Androgen receptor; Lipid metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008290388,0.0001128529,0.0001590731,0.0000396881,0.00001781369,0.000005742621,0.00007649644,0.0000527991,0.0000106603],"category_scores_gemma":[0.00006173316,0.0001105776,0.00005811377,0.000145359,0.00002900619,0.000003256345,0.00002592734,0.00002532506,0.000001327465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003882983,"about_ca_system_score_gemma":0.0009374594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001642205,"about_ca_topic_score_gemma":0.001246548,"domain_scores_codex":[0.9992603,0.00004914414,0.0001640283,0.0002631976,0.00006817395,0.0001951259],"domain_scores_gemma":[0.9996226,0.000007825436,0.00005444932,0.0001515987,0.00004298686,0.0001205856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002469945,0.000008200534,0.003040841,0.00001950589,0.00002841772,2.197907e-7,0.001206159,0.01476437,0.9584862,0.00000253515,0.0007838345,0.01918979],"study_design_scores_gemma":[0.001376943,0.0005102477,0.03384469,0.00002056786,0.00002587115,0.000001174935,0.0002393462,0.0004418502,0.6402081,0.000005924645,0.3231393,0.0001860084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963909,0.001732665,0.00009737565,0.00062007,0.0007035966,0.0003169452,0.00009102609,0.000007012607,0.00004045395],"genre_scores_gemma":[0.99543,0.001222786,0.0002906697,0.0007675833,0.001701623,0.0001923903,0.00001390608,0.00001932479,0.0003617096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3223554,"threshold_uncertainty_score":0.4509222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01268579273259808,"score_gpt":0.2700803002505834,"score_spread":0.2573945075179853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}