{"id":"W3103917633","doi":"10.3390/cancers12113339","title":"Modulation of de Novo Lipogenesis Improves Response to Enzalutamide Treatment in Prostate Cancer","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; University of British Columbia; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Enzalutamide; Prostate cancer; Lipogenesis; Cancer research; LNCaP; Internal medicine; Cancer; Medicine; Cancer cell; Endocrinology; Oncology; Androgen receptor; Lipid metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166731,0.0003615516,0.0005690649,0.0002868617,0.0001368627,0.0003025341,0.0002805347,0.0002051606,0.001006942],"category_scores_gemma":[0.0001030659,0.0001252398,0.0002059593,0.0002429533,0.0001621724,0.0001410467,0.000155442,0.0007698001,0.0001559751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002460008,"about_ca_system_score_gemma":0.0003620236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001464577,"about_ca_topic_score_gemma":0.003106482,"domain_scores_codex":[0.9999038,0.00001999098,0.000009810963,0.00001798472,0.00002224261,0.00002610592],"domain_scores_gemma":[0.9999411,0.000007844521,0.00001266586,0.000005425146,0.000006457566,0.00002650717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002765154,0.000709085,0.0005144657,0.0001272913,0.00004442773,0.00006528623,0.000027673,0.0003845694,0.9791601,0.00005722686,0.0001981611,0.01594659],"study_design_scores_gemma":[0.0005492831,0.02031398,0.01781772,0.00001975512,0.0002008019,0.000470958,0.00007035417,0.001948766,0.9506918,0.00007737683,0.007813444,0.0000256813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945925,0.003580643,0.000557042,0.0001182746,0.00005884885,0.00003790505,0.0002052791,0.0001264934,0.0007230567],"genre_scores_gemma":[0.996204,0.001597897,0.0006554026,0.00006110789,0.00001320819,0.00002424788,0.0002977895,0.00001492516,0.00113156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001464577,"threshold_uncertainty_score":0.003368497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01268579273259808,"score_gpt":0.2700803002505834,"score_spread":0.2573945075179853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}