{"id":"W3103985965","doi":"10.1172/jci.insight.141293","title":"A soluble activator that favors the ex vivo expansion of CD8+CD27+ T cells","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Hospital","funders":"Canadian Institutes of Health Research","keywords":"CD28; Ex vivo; Cytotoxic T cell; T cell; CD8; Chemistry; Population; Cell biology; Molecular biology; Biology; Immunology; In vitro; Immune system; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001831465,0.0001704276,0.0003549407,0.00007123307,0.00007950304,0.00002441876,0.0002505554,0.0001174416,0.006329093],"category_scores_gemma":[0.00007353528,0.0001065621,0.0001764371,0.0003895394,0.0001381933,0.0001029187,0.0001454144,0.0003973513,0.0001675422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006320017,"about_ca_system_score_gemma":0.0001975762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001246887,"about_ca_topic_score_gemma":0.00000841472,"domain_scores_codex":[0.9983413,0.00009799765,0.0002345189,0.0003012805,0.0007078275,0.0003171309],"domain_scores_gemma":[0.9988537,0.0001883258,0.0000908118,0.0005338311,0.00009975681,0.0002335106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005538549,0.00009766964,0.0004521567,0.0001019947,0.00007410062,0.00003037926,0.0047605,0.000004285033,0.964922,0.00004880077,0.02567552,0.003278735],"study_design_scores_gemma":[0.0008779193,0.0003410589,0.0002441491,0.00004294343,0.00002564164,0.00000482792,0.0006032879,0.000234688,0.7061753,0.00001961394,0.2913477,0.00008286941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9473853,0.000585218,0.0001324067,0.007268192,0.0003763884,0.0009753956,0.0000102366,0.0000925783,0.04317435],"genre_scores_gemma":[0.9851003,0.0003184094,0.0001309151,0.002001062,0.0003647773,0.0000193888,0.000006940224,0.00004936712,0.0120088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2656722,"threshold_uncertainty_score":0.9945793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06198926715532612,"score_gpt":0.3009758882724902,"score_spread":0.2389866211171641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}