{"id":"W3104112957","doi":"10.1007/s13311-020-00965-9","title":"BDNF rs6265 Variant Alters Outcomes with Levodopa in Early-Stage Parkinson's Disease","year":2020,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Genentech; Boston Scientific Corporation; Vanderbilt University Medical Center; Saint Mary's Foundation; Allergan; National Institutes of Health; Ipsen; H. Lundbeck A/S; Weston Brain Institute; Vanderbilt University; American Parkinson Disease Association; U.S. Department of Defense","keywords":"rs6265; Levodopa; Internal medicine; Oncology; Parkinson's disease; Single-nucleotide polymorphism; Medicine; Selegiline; Disease; Genotype; Psychology; Brain-derived neurotrophic factor; Genetics; Neurotrophic factors; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006188778,0.0002186977,0.0001962485,0.00006601326,0.0001073543,0.0001002048,0.0002691724,0.00004342076,0.00004802163],"category_scores_gemma":[0.00006472596,0.0001672836,0.0000628049,0.0003552576,0.000106196,0.000209618,0.000029283,0.0002540603,0.00005119771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001830395,"about_ca_system_score_gemma":0.000062713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001234684,"about_ca_topic_score_gemma":0.00001373335,"domain_scores_codex":[0.9983819,0.0002196263,0.0002293536,0.0005241178,0.0003331714,0.0003118024],"domain_scores_gemma":[0.9992705,0.0001181026,0.00008578473,0.0002902262,0.00001507038,0.0002203114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002388965,0.0008222621,0.3742749,0.0001737579,0.00004000421,0.004241439,0.003171815,0.01003318,0.5775275,0.02023234,0.0002756105,0.006818208],"study_design_scores_gemma":[0.005149596,0.001759126,0.2323145,0.00006041396,0.00009869333,0.00003179339,0.00008454629,0.03038347,0.4867038,0.0003919587,0.241564,0.001458086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98759,0.00002658442,0.001621265,0.00938193,0.0002354407,0.0004716077,0.00004399937,0.0001332646,0.0004958982],"genre_scores_gemma":[0.9741706,0.00004528071,0.0001485619,0.02493732,0.00009210088,0.00002639138,0.000001902213,0.00004843288,0.00052943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2412884,"threshold_uncertainty_score":0.6821628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06420135401948456,"score_gpt":0.277333290486667,"score_spread":0.2131319364671824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}