{"id":"W3104112957","doi":"10.1007/s13311-020-00965-9","title":"BDNF rs6265 Variant Alters Outcomes with Levodopa in Early-Stage Parkinson's Disease","year":2020,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Genentech; Boston Scientific Corporation; Vanderbilt University Medical Center; Saint Mary's Foundation; Allergan; National Institutes of Health; Ipsen; H. Lundbeck A/S; Weston Brain Institute; Vanderbilt University; American Parkinson Disease Association; U.S. Department of Defense","keywords":"rs6265; Levodopa; Internal medicine; Oncology; Parkinson's disease; Single-nucleotide polymorphism; Medicine; Selegiline; Disease; Genotype; Psychology; Brain-derived neurotrophic factor; Genetics; Neurotrophic factors; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000191898,0.0003742695,0.0004458285,0.0003105622,0.0003996887,0.000572991,0.0002898266,0.0007535546,0.002991347],"category_scores_gemma":[0.0009403214,0.0001503122,0.0006424452,0.0004235727,0.0002230414,0.0003142509,0.0002606107,0.0004331095,0.0003777445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002387103,"about_ca_system_score_gemma":0.0001532194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004674671,"about_ca_topic_score_gemma":0.006683702,"domain_scores_codex":[0.9998268,0.00002683941,0.0000298753,0.0000627236,0.00002227789,0.00003142826],"domain_scores_gemma":[0.9996248,0.00009453855,0.0001737394,0.00001954796,0.00003639787,0.00005090181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0100859,0.0003040036,0.9422912,0.0001380202,0.001509652,0.003652609,0.0004403576,0.0003431243,0.0152456,0.0002410287,0.0007495141,0.02499912],"study_design_scores_gemma":[0.00005712864,0.0004213596,0.9952513,0.00004198982,0.0004660344,0.001768838,0.0001843726,0.0003209862,0.0006136197,0.0003367859,0.0005213601,0.00001621458],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982724,0.0006517131,0.00006328808,0.00007596483,0.00001695855,0.000002752383,0.0002939883,0.000005749746,0.0006171364],"genre_scores_gemma":[0.9991424,0.0001151736,0.00004349674,0.00003086691,0.00001117218,0.000002202997,0.0001776786,0.000003360874,0.0004735495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004674671,"threshold_uncertainty_score":0.01000708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06420135401948456,"score_gpt":0.277333290486667,"score_spread":0.2131319364671824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}