{"id":"W3104170303","doi":"10.7573/dic.2020-8-5","title":"Emerging systemic JAK inhibitors in the treatment of atopic dermatitis: a review of abrocitinib, baricitinib, and upadacitinib","year":2020,"lang":"en","type":"review","venue":"Drugs in Context","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Queen's University; Trent University; SKiN Health","funders":"","keywords":"Medicine; Janus kinase; Rheumatoid arthritis; Psoriatic arthritis; Tyrosine kinase 2; Atopic dermatitis; Psoriasis; Clinical trial; Adverse effect; Immunology; Pharmacology; Cytokine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002941951,0.000394,0.003301215,0.0002395311,0.00002573223,0.000006516571,0.0001913213,0.0002178628,0.00005001968],"category_scores_gemma":[0.0002888404,0.0002575843,0.000468601,0.0005069225,0.0001746532,0.00004282273,0.00003548218,0.0002764833,0.00001001594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009037245,"about_ca_system_score_gemma":0.0003252882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005764862,"about_ca_topic_score_gemma":0.00001680798,"domain_scores_codex":[0.9968532,0.0005979137,0.001697524,0.0003507522,0.0002638801,0.0002367588],"domain_scores_gemma":[0.9979306,0.00088864,0.0006440163,0.000396451,0.00006085309,0.00007941491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007206556,0.0001775215,0.000952868,0.2447029,0.0001373376,0.0002262938,0.002607412,1.267552e-8,6.900593e-8,0.0001561147,0.001202545,0.7498296],"study_design_scores_gemma":[0.001052209,0.00008954562,0.0001679518,0.326066,0.0009144118,0.0005182169,0.001654696,0.000002237409,0.000002584333,0.00001629414,0.6693614,0.0001544731],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001101854,0.9941347,0.000001060312,0.0004618614,0.0001095371,0.002280854,0.00009913994,0.00001400162,0.001797002],"genre_scores_gemma":[0.03674313,0.9619129,0.00001344203,0.0007058066,0.00006560634,0.0003926098,0.0001104735,0.00002712694,0.00002889331],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7496752,"threshold_uncertainty_score":0.9999877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635043471472395,"score_gpt":0.3322106738344878,"score_spread":0.3058602391197638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}