{"id":"W3104370277","doi":"10.1021/acs.biochem.0c00450","title":"Post-Translational Modifications of Platelet-Derived Amyloid Precursor Protein by Coagulation Factor XIII-A*","year":2020,"lang":"en","type":"article","venue":"Biochemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Canada Foundation for Innovation; Weston Brain Institute","keywords":"Platelet; Amyloid precursor protein; Chemistry; Coagulation; Proteases; Factor XIII; Platelet activation; Tissue transglutaminase; Biochemistry; Fibrin; Covalent bond; Nicastrin; Platelet factor 4; Cell biology; Enzyme; Alzheimer's disease; Fibrinogen; Immunology; Heparin; Biology; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473569,0.0003040585,0.000143528,0.00009000721,0.0001252069,0.0002280342,0.000106804,0.0002392925,0.0009901475],"category_scores_gemma":[0.0002553246,0.0001240293,0.0002456696,0.0001005009,0.0001733447,0.0001450984,0.000133621,0.000377771,0.0002763394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001878907,"about_ca_system_score_gemma":0.000137654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005850621,"about_ca_topic_score_gemma":0.0004037766,"domain_scores_codex":[0.9998719,0.00003233551,0.000008007311,0.00002664401,0.00002343593,0.00003773132],"domain_scores_gemma":[0.9999051,0.00002758874,0.00002676641,0.00001140353,0.0000105595,0.00001840717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004287352,0.00003647893,0.0004139613,0.00002929563,0.00001598047,0.0001797163,0.00002531303,0.00005180293,0.9964161,0.0001729568,0.00005533775,0.002174255],"study_design_scores_gemma":[0.00001725677,0.0003242556,0.007557252,0.000004622322,0.00001339161,0.0003277542,0.0000152926,0.0004014465,0.9896817,0.00006874577,0.001583823,0.00000443125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955624,0.001619703,0.001556644,0.00006187095,0.00002934989,0.00001881419,0.00007103247,0.00001574305,0.001064427],"genre_scores_gemma":[0.9962938,0.0007263037,0.00106926,0.00004908016,0.00001832726,0.00001912955,0.0001643837,0.000008832983,0.001650918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009901475,"threshold_uncertainty_score":0.003312409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0231749359273405,"score_gpt":0.2382700202659598,"score_spread":0.2150950843386193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}