{"id":"W3104370277","doi":"10.1021/acs.biochem.0c00450","title":"Post-Translational Modifications of Platelet-Derived Amyloid Precursor Protein by Coagulation Factor XIII-A*","year":2020,"lang":"en","type":"article","venue":"Biochemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Canada Foundation for Innovation; Weston Brain Institute","keywords":"Platelet; Amyloid precursor protein; Chemistry; Coagulation; Proteases; Factor XIII; Platelet activation; Tissue transglutaminase; Biochemistry; Fibrin; Covalent bond; Nicastrin; Platelet factor 4; Cell biology; Enzyme; Alzheimer's disease; Fibrinogen; Immunology; Heparin; Biology; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002586037,0.0001209696,0.000173794,0.00001520411,0.00004604307,0.00001023515,0.00006982771,0.0001370408,0.0003428088],"category_scores_gemma":[0.00006599882,0.000112807,0.00007379527,0.0001082219,0.00005577816,0.00005753253,0.00001322105,0.0001074172,0.00001965182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001763296,"about_ca_system_score_gemma":0.0001147408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000156771,"about_ca_topic_score_gemma":2.725084e-7,"domain_scores_codex":[0.9991285,0.00001206786,0.0002772813,0.0002259152,0.0002386278,0.0001176089],"domain_scores_gemma":[0.999421,0.00001234605,0.0001162205,0.0001646892,0.0001837107,0.0001020168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002374666,0.00009196976,0.000539076,0.0002162628,0.00004386726,4.426596e-7,0.0002324772,0.000009540601,0.9959015,0.00001659901,0.0005336376,0.002177164],"study_design_scores_gemma":[0.0007948819,0.0001093481,0.004927427,0.00004760081,0.00003437503,0.000003566199,0.00006920323,0.001836028,0.9909171,0.00001347852,0.001130391,0.0001166423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922451,0.0006355825,0.0008217872,0.004861555,0.00001508222,0.000457663,0.0003130137,0.00006228072,0.0005878801],"genre_scores_gemma":[0.9976426,0.000005876045,0.0007306891,0.0001956898,0.00008724823,0.0000336301,0.0007612172,0.00001755749,0.0005255166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00539742,"threshold_uncertainty_score":0.4600137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0231749359273405,"score_gpt":0.2382700202659598,"score_spread":0.2150950843386193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}