{"id":"W3104453027","doi":"10.1101/2020.10.12.336487","title":"Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Synthetic lethality; Poliovirus; Lethality; Virology; Biology; Function (biology); Viral protein; Mutation; Host (biology); Nuclear transport; RNA; Virus; Cell biology; Cancer cell; Cancer; DNA; Genetics; Cell nucleus; Gene; DNA repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690851,0.0004072989,0.0001701342,0.0001890264,0.0001225862,0.0002742551,0.0001378891,0.0003364718,0.001606214],"category_scores_gemma":[0.00009390444,0.0001092653,0.0001899355,0.00009949976,0.0002607733,0.0001410414,0.0003504586,0.0006983771,0.0003995034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002515254,"about_ca_system_score_gemma":0.0001370285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002422127,"about_ca_topic_score_gemma":0.0003377992,"domain_scores_codex":[0.9998592,0.00002393639,0.00001008102,0.00002311357,0.00005089015,0.00003264047],"domain_scores_gemma":[0.9999343,0.00001468139,0.00001766083,0.00001172086,0.000005503494,0.00001611419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003368685,0.000008460055,0.00009628007,0.00001297303,0.000002368222,0.00002995154,0.000004772629,0.00004077377,0.998942,0.0001421572,0.00005480132,0.0006317488],"study_design_scores_gemma":[0.000006465891,0.00007690752,0.001027258,0.000001950692,0.000003281965,0.000200098,0.000008392131,0.0005391173,0.9960399,0.00005525517,0.002039585,0.00000190084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881387,0.001000596,0.00626061,0.0003068536,0.00006211652,0.00003376367,0.0004605008,0.0001818751,0.003554896],"genre_scores_gemma":[0.9936103,0.0003954915,0.002227037,0.0001277932,0.000009689658,0.00003422144,0.0005107558,0.0000365196,0.003048085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001606214,"threshold_uncertainty_score":0.005373359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02841804235867915,"score_gpt":0.2490698511815921,"score_spread":0.220651808822913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}