{"id":"W3104530872","doi":"10.7554/elife.60151.sa2","title":"Author response: eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis","year":2020,"lang":"en","type":"peer-review","venue":"","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Phosphorylation; Carcinogenesis; Cell biology; Cancer research; EIF4E; Computational biology; Biology; Chemistry; Neuroscience; Genetics; Cancer; Gene; Translation (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001352472,0.0004973121,0.0004636993,0.001143861,0.0006791533,0.002140708,0.0006261399,0.001737328,0.17177],"category_scores_gemma":[0.0059883,0.0002705228,0.0003538727,0.0006160053,0.0006745411,0.0009049045,0.001113153,0.001072163,0.07299935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006554577,"about_ca_system_score_gemma":0.001630728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008016427,"about_ca_topic_score_gemma":0.001410011,"domain_scores_codex":[0.9987202,0.0001283857,0.00007861232,0.0001680114,0.0007428849,0.0001620282],"domain_scores_gemma":[0.9957474,0.0007298464,0.0002956596,0.0004443574,0.001993689,0.0007889812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001617622,0.0001770049,0.002310679,0.001383002,0.00008544536,0.00198122,0.0002197325,0.0008000018,0.1665644,0.01156026,0.6380331,0.1752676],"study_design_scores_gemma":[0.0000896,0.000106303,0.004681832,0.00006867295,0.00001533716,0.0009712756,0.0001915116,0.0006647406,0.07313938,0.001819907,0.9182223,0.00002913147],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.1440362,0.01679047,0.01839256,0.08052526,0.1682747,0.001315658,0.02004234,0.01117141,0.5394516],"genre_scores_gemma":[0.2041102,0.005526394,0.005275473,0.003068916,0.005295386,0.0001255805,0.006488289,0.001313415,0.7687963],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.17177,"threshold_uncertainty_score":0.5746279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03595785726504581,"score_gpt":0.3332501193812041,"score_spread":0.2972922621161583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}