{"id":"W3104539917","doi":"10.1016/j.trecan.2020.10.010","title":"Beyond Kinases: Targeting Replication Stress Proteins in Cancer Therapy","year":2020,"lang":"en","type":"review","venue":"Trends in cancer","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Terry Fox Research Institute","funders":"Terry Fox Research Institute","keywords":"DNA re-replication; Biology; DNA replication; Helicase; Kinase; Control of chromosome duplication; Genetics; Eukaryotic DNA replication; Pre-replication complex; Cell biology; DNA; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000203477,0.0004058514,0.0007898761,0.0001357538,0.00002823489,0.00002287246,0.0004231157,0.0004291195,0.0002382034],"category_scores_gemma":[0.00003837542,0.0003653155,0.0002330876,0.0005648254,0.00003466175,0.000004913086,0.000130126,0.0003426933,0.000004530235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002690509,"about_ca_system_score_gemma":0.0003218869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007516437,"about_ca_topic_score_gemma":0.002038768,"domain_scores_codex":[0.9977268,0.0001614057,0.0005483785,0.001043172,0.0001746038,0.0003456647],"domain_scores_gemma":[0.9988422,0.00001121397,0.0003401334,0.0006997712,0.000036641,0.0000700265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002151598,0.00006592368,0.00006496206,0.0009806689,0.00006009666,0.00001005053,0.00005674756,0.00001779022,0.001274163,0.00001447626,0.0009702075,0.9964634],"study_design_scores_gemma":[0.0003487995,0.0001039403,0.00001769161,0.002079344,0.00004147826,0.000001667494,0.00001182796,0.00001292508,0.007304146,0.00001742066,0.9896606,0.0004001414],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004814625,0.9973854,0.000009159707,0.0001206905,0.0002535794,0.0006774702,0.0003065907,0.00002462855,0.000741002],"genre_scores_gemma":[0.0004075001,0.9933926,0.0002491316,0.0001280537,0.0005901988,0.003544839,0.0008183676,0.00009522439,0.0007740728],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9960632,"threshold_uncertainty_score":0.9998799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05058309301374043,"score_gpt":0.3820710126838874,"score_spread":0.331487919670147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}