{"id":"W3104553874","doi":"10.1161/circ.142.suppl_3.14127","title":"Abstract 14127: BET Protein Inhibitor Apabetalone Suppresses Inflammatory Hyperactivation of Monocytes From Patients With Cardiovascular Disease and Type 2 Diabetes","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Medicine; Proinflammatory cytokine; Ex vivo; Monocyte; CD14; Immunology; Chemokine; Tumor necrosis factor alpha; Cytokine; Inflammation; Cancer research; In vivo; Biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009969198,0.0003150131,0.0004254652,0.0001566924,0.0001274517,0.0002027612,0.0001235688,0.0001500433,0.003183456],"category_scores_gemma":[0.0001270567,0.00009979814,0.000199407,0.000148314,0.0001090029,0.00006548949,0.0001717616,0.0004807079,0.0004375304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008104002,"about_ca_system_score_gemma":0.0001796389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002277298,"about_ca_topic_score_gemma":0.0003656976,"domain_scores_codex":[0.9999387,0.00001372331,0.000005794752,0.00001120875,0.00001267638,0.00001783666],"domain_scores_gemma":[0.9999499,0.000006580995,0.000009662353,0.000004098199,0.000005534413,0.00002424787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01286636,0.0009140074,0.004649343,0.0003286973,0.00008732501,0.0002194999,0.00004282214,0.0001586005,0.951862,0.00005347278,0.0008495989,0.02796813],"study_design_scores_gemma":[0.004453271,0.04603688,0.1609328,0.00008426591,0.0004441808,0.002022717,0.0002210907,0.001752302,0.7669976,0.0002140797,0.01680395,0.00003684705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960716,0.002147964,0.0004225698,0.00009479559,0.00005868012,0.00003693641,0.000504879,0.00005107005,0.000611562],"genre_scores_gemma":[0.9942483,0.001123134,0.0008211713,0.0001438418,0.00004743317,0.00009324717,0.001322113,0.00001040997,0.002190423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003183456,"threshold_uncertainty_score":0.01064974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008915228993306464,"score_gpt":0.184900174994522,"score_spread":0.1759849460012155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}