{"id":"W3104643303","doi":"10.1113/jp280749","title":"PKCε stimulation of TRPV1 orchestrates carotid body responses to asthmakines","year":2020,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Children's Hospital Research Institute; Canadian Institutes of Health Research; Alberta Innovates","keywords":"TRPV1; Bronchoconstriction; Carotid body; Stimulation; Medicine; Protein kinase C; Methacholine; Reflex; Lysophosphatidic acid; Transient receptor potential channel; Internal medicine; Endocrinology; Pharmacology; Immunology; Neuroscience; Signal transduction; Biology; Receptor; Asthma; Lung; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969371,0.00007206398,0.0001948404,0.00005112174,0.00005325873,0.000004324885,0.0002509105,0.00003287418,0.00007223143],"category_scores_gemma":[0.0006402404,0.00003971067,0.00006515784,0.0001919556,0.0000949656,0.00006338611,0.00004386477,0.0001345111,0.00001541463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006942659,"about_ca_system_score_gemma":0.00004471847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004571564,"about_ca_topic_score_gemma":2.854214e-7,"domain_scores_codex":[0.9990263,0.000384285,0.0002700012,0.00007756001,0.0001303487,0.0001114819],"domain_scores_gemma":[0.9990315,0.0004997827,0.0002601409,0.00006117092,0.00008526319,0.00006210383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006795212,0.00002345525,0.00003662047,0.000009127572,0.00000469388,0.000001092087,0.001000118,0.008069701,0.9894366,0.0001000401,0.0005224023,0.00011664],"study_design_scores_gemma":[0.0002152086,0.00103167,0.009677673,0.00001484602,0.00001094679,0.0000242253,0.0001885352,0.0008063241,0.9871565,0.0004179984,0.0004072047,0.00004888107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959235,0.00002522559,0.0001292091,0.003511355,0.0002835486,0.00007376404,0.000004069283,0.000005597589,0.00004369521],"genre_scores_gemma":[0.9988258,0.00003890935,0.00005150849,0.0007073603,0.0003222514,4.669943e-7,1.758163e-7,0.000006736932,0.00004674781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009641052,"threshold_uncertainty_score":0.1619354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06359923866111006,"score_gpt":0.3136230710330722,"score_spread":0.2500238323719621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}