{"id":"W3104643303","doi":"10.1113/jp280749","title":"PKCε stimulation of TRPV1 orchestrates carotid body responses to asthmakines","year":2020,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Children's Hospital Research Institute; Canadian Institutes of Health Research; Alberta Innovates","keywords":"TRPV1; Bronchoconstriction; Carotid body; Stimulation; Medicine; Protein kinase C; Methacholine; Reflex; Lysophosphatidic acid; Transient receptor potential channel; Internal medicine; Endocrinology; Pharmacology; Immunology; Neuroscience; Signal transduction; Biology; Receptor; Asthma; Lung; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002577795,0.0004154021,0.0003238675,0.0002571172,0.0002732086,0.0004846804,0.0002837689,0.0005456491,0.002996732],"category_scores_gemma":[0.0002565543,0.0001955757,0.0005793361,0.0001784412,0.0004778311,0.0004880283,0.0003870982,0.001139247,0.001091946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005161719,"about_ca_system_score_gemma":0.000370885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004736753,"about_ca_topic_score_gemma":0.0005557151,"domain_scores_codex":[0.9996542,0.00004179484,0.00002376035,0.00007956738,0.00006491808,0.0001357442],"domain_scores_gemma":[0.9998577,0.00002048676,0.0000371244,0.0000222325,0.00002365223,0.00003895694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002314488,0.0000296329,0.0001686207,0.0000892305,0.000003366834,0.00004119456,0.00001758166,0.00003907102,0.9983667,0.0000945311,0.0000481492,0.0008705059],"study_design_scores_gemma":[0.00004818482,0.0003809514,0.01485408,0.00003739612,0.00004270648,0.0003650461,0.0001222996,0.001479238,0.9795155,0.0002220655,0.002923675,0.000008766375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775414,0.00756457,0.008800589,0.0008037117,0.0002521137,0.00006450126,0.0005601293,0.0001602742,0.004252885],"genre_scores_gemma":[0.991663,0.002475023,0.001711832,0.0001404588,0.00006923978,0.00006937409,0.0003680902,0.00002504391,0.003478039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002996732,"threshold_uncertainty_score":0.01002508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06359923866111006,"score_gpt":0.3136230710330722,"score_spread":0.2500238323719621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}