{"id":"W3104643362","doi":"10.1016/j.biopsych.2020.11.009","title":"Dynamics of Cortical Degeneration Over a Decade in Huntington’s Disease","year":2020,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UK Dementia Research Institute; IXICO; Universität Ulm; University of British Columbia; Deutsches Zentrum für Neurodegenerative Erkrankungen; Monash University; Assistance publique-Hôpitaux de Paris; Westfälische Wilhelms-Universität Münster; Alzheimer’s Research UK; Universiteit Leiden; University of Manchester; Massachusetts General Hospital; National Institute for Health and Care Research; CHDI Foundation; University of Oxford; Alzheimer's Society; Wellcome Trust; Indiana University; Medical Research Council; London School of Hygiene and Tropical Medicine; University College London; Imperial College London; University of Iowa","keywords":"Huntington's disease; Degeneration (medical); Neuroscience; Disease; Dynamics (music); Neuronal degeneration; Psychology; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00089275,0.0001532155,0.00020649,0.0007191234,0.0001670492,0.0003776424,0.000221557,0.0002887399,0.0007681253],"category_scores_gemma":[0.003315226,0.0001644457,0.0002805729,0.0004680012,0.0002282998,0.0003281263,0.0003446496,0.0002674647,0.0001234504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004948952,"about_ca_system_score_gemma":0.0002685215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008799149,"about_ca_topic_score_gemma":0.01128577,"domain_scores_codex":[0.9998785,0.00003659725,0.000009062775,0.00004554966,0.00001650769,0.00001381],"domain_scores_gemma":[0.9989786,0.0005330479,0.0002468273,0.00007028276,0.000100852,0.00007030916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004928434,0.0001117224,0.8248259,0.0001158076,0.0003295994,0.0006662144,0.0005978101,0.1320888,0.007655597,0.001300098,0.001359195,0.03045649],"study_design_scores_gemma":[0.00001470478,0.0001188603,0.8263756,0.00003002299,0.00005451844,0.0004424608,0.0002077504,0.1676039,0.001091269,0.003210012,0.0008249306,0.00002601268],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956883,0.000243224,0.003010473,0.00007281011,0.000002406808,0.000006967711,0.0007118316,0.00002356234,0.0002404695],"genre_scores_gemma":[0.9977714,0.0001058544,0.001054409,0.000009503314,0.000002337112,0.00001103755,0.0009064887,0.00000400714,0.0001349901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008799149,"threshold_uncertainty_score":0.01749581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04488645605634711,"score_gpt":0.291150336268861,"score_spread":0.2462638802125139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}