{"id":"W3104643362","doi":"10.1016/j.biopsych.2020.11.009","title":"Dynamics of Cortical Degeneration Over a Decade in Huntington’s Disease","year":2020,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UK Dementia Research Institute; IXICO; Universität Ulm; University of British Columbia; Deutsches Zentrum für Neurodegenerative Erkrankungen; Monash University; Assistance publique-Hôpitaux de Paris; Westfälische Wilhelms-Universität Münster; Alzheimer’s Research UK; Universiteit Leiden; University of Manchester; Massachusetts General Hospital; National Institute for Health and Care Research; CHDI Foundation; University of Oxford; Alzheimer's Society; Wellcome Trust; Indiana University; Medical Research Council; London School of Hygiene and Tropical Medicine; University College London; Imperial College London; University of Iowa","keywords":"Huntington's disease; Degeneration (medical); Neuroscience; Disease; Dynamics (music); Neuronal degeneration; Psychology; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005533029,0.0001485894,0.0001856095,0.00003907806,0.0000572983,0.00001635333,0.0002331248,0.00007314514,0.0001368725],"category_scores_gemma":[0.001421871,0.0001187964,0.00009608351,0.0003121558,0.0001561065,0.00004350288,0.00009132535,0.0001656481,0.00002536125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001809409,"about_ca_system_score_gemma":0.00008553486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002795301,"about_ca_topic_score_gemma":0.00001553127,"domain_scores_codex":[0.9984373,0.0002768914,0.0003464056,0.0005249069,0.0001836031,0.0002308995],"domain_scores_gemma":[0.999359,0.0001169235,0.00008949253,0.0001637119,0.00001881958,0.0002520408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002504805,0.0003275639,0.6537142,0.00002324759,0.00000149266,0.000004106542,0.0000275475,0.0003050502,0.3144296,0.03051622,0.0002233466,0.0001772077],"study_design_scores_gemma":[0.0006589426,0.0002904748,0.8965257,0.00001416763,0.00001245586,5.119838e-7,0.00003515549,0.01051785,0.08835486,0.003291801,0.00005805936,0.0002400659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941844,0.00007370007,0.0005884875,0.004368282,0.0002457913,0.0002282226,0.00007666077,0.00004742599,0.0001869923],"genre_scores_gemma":[0.994495,0.00002703426,0.0005939633,0.004694443,0.0001395239,0.00001726224,0.00001533467,0.00001076354,0.000006616476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2428115,"threshold_uncertainty_score":0.4844376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04488645605634711,"score_gpt":0.291150336268861,"score_spread":0.2462638802125139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}