{"id":"W3104685239","doi":"10.25251/skin.4.supp.93","title":"The Safety and Efficacy of Roflumilast Cream 0.15% and 0.05% in Atopic Dermatitis: Phase 2 Proof-of-Concept Study","year":2020,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada); Probity Medical Research; Queen's University","funders":"","keywords":"Atopic dermatitis; Roflumilast; Proof of concept; Medicine; Dermatology; Computer science; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00286155,0.001796032,0.002527138,0.0004340374,0.0004363292,0.001433083,0.001392403,0.001695647,0.007179512],"category_scores_gemma":[0.001345162,0.0008974851,0.002150343,0.0003582433,0.001159839,0.00141344,0.0003288826,0.004178675,0.001692898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000734708,"about_ca_system_score_gemma":0.001707896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006449906,"about_ca_topic_score_gemma":0.001411238,"domain_scores_codex":[0.9992362,0.0003517948,0.0000425689,0.0001202351,0.0001033061,0.0001460035],"domain_scores_gemma":[0.9991559,0.0002513372,0.000159824,0.0001166335,0.00009854698,0.0002178028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6051555,0.129661,0.0008997092,0.005572935,0.002075763,0.0003337668,0.000392469,0.001440651,0.140679,0.0006215905,0.005852036,0.1073157],"study_design_scores_gemma":[0.3050886,0.669199,0.004166768,0.0001648991,0.0009765787,0.0003192921,0.00010631,0.0008033332,0.01216208,0.0003038444,0.006654607,0.00005459238],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658486,0.01418582,0.002892686,0.0009557077,0.0008342045,0.008859785,0.002612588,0.0003020673,0.003508567],"genre_scores_gemma":[0.9678603,0.009845781,0.005343337,0.001405505,0.0005358094,0.00701261,0.002182445,0.00008767092,0.005726515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007179512,"threshold_uncertainty_score":0.02401781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259036974305243,"score_gpt":0.2879166144450862,"score_spread":0.2753262447020338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}