{"id":"W3104897542","doi":"10.1101/2020.11.19.389072","title":"ATP triggers macropinocytosis that internalizes and is regulated by PANX1","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; University of Victoria","keywords":"Internalization; Pinocytosis; Cell biology; Biology; Adenosine triphosphate; Adenosine; Small GTPase; Pannexin; Extracellular; GTP'; Intracellular; Cell; Endocytosis; Chemistry; Biochemistry; Signal transduction; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006935649,0.0001637939,0.0001656455,0.0001124752,0.0001211857,0.0002724462,0.00009051158,0.0002201815,0.001108785],"category_scores_gemma":[0.00006885848,0.00009343674,0.0001545996,0.00008640056,0.0001311951,0.0001653823,0.0001965745,0.0002993625,0.0003622986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000239569,"about_ca_system_score_gemma":0.0001048332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00046965,"about_ca_topic_score_gemma":0.0005624343,"domain_scores_codex":[0.9999298,0.000007111119,0.000005757447,0.00001488089,0.00002458926,0.00001795163],"domain_scores_gemma":[0.9999664,0.000008588912,0.000007600514,0.000005116187,0.000003698212,0.000008630558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000524305,0.000004445101,0.0001361021,0.00001069768,0.000001430392,0.00008385564,0.000007040128,0.00003672687,0.9990942,0.0001014349,0.00003832866,0.0004332805],"study_design_scores_gemma":[0.000007726356,0.000049718,0.007334406,0.000003220882,0.0000036002,0.0002307943,0.00002562582,0.001206317,0.9892851,0.00008009326,0.001770623,0.000002739935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994144,0.0007698261,0.002019936,0.0001076302,0.00003802837,0.00001116414,0.000314194,0.00006911629,0.002526159],"genre_scores_gemma":[0.9942132,0.0005657359,0.001295124,0.00005295374,0.00001322699,0.00001980175,0.000393097,0.00002205075,0.003424877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108785,"threshold_uncertainty_score":0.003709316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520222880279834,"score_gpt":0.2227037755169614,"score_spread":0.2075015467141631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}