{"id":"W3104946688","doi":"10.1186/s41181-020-00111-y","title":"Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting, 111In or β-particle emitting, 177Lu","year":2020,"lang":"en","type":"article","venue":"EJNMMI Radiopharmacy and Chemistry","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Foundation; University of Toronto; Canadian Cancer Society","keywords":"Panitumumab; DOTA; Radioimmunotherapy; Cancer research; Radionuclide therapy; Chemistry; Molecular biology; Medicine; Monoclonal antibody; Cetuximab; Internal medicine; Immunology; Biology; Antibody; Chelation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00053273,0.0009685299,0.0006231347,0.000673313,0.0002564545,0.0003523961,0.0004916134,0.0007019737,0.001685329],"category_scores_gemma":[0.0001624476,0.0004312044,0.0006539583,0.0003012608,0.0004190029,0.0004557933,0.0001767463,0.001547199,0.0005269113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005300127,"about_ca_system_score_gemma":0.0004122553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159392,"about_ca_topic_score_gemma":0.001455188,"domain_scores_codex":[0.9995999,0.00007815425,0.00003594844,0.0001140636,0.00007214362,0.00009988574],"domain_scores_gemma":[0.999742,0.00004497791,0.00007586127,0.00005188818,0.00001765228,0.00006756886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001952009,0.0008104048,0.0002709673,0.00006039741,0.00002093856,0.00006726474,0.00004124382,0.000251133,0.9946055,0.0001624475,0.0001604156,0.001597277],"study_design_scores_gemma":[0.0002827127,0.009200298,0.003379137,0.00001340304,0.00005081619,0.0003614544,0.00002980767,0.00199922,0.9825916,0.00005787556,0.002024675,0.000008851718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914134,0.00108507,0.00213623,0.0002239212,0.0001021726,0.0002102925,0.001114036,0.0002828624,0.003432163],"genre_scores_gemma":[0.9807333,0.00117735,0.005242742,0.0001524494,0.00004479337,0.0003762436,0.001760189,0.00008204074,0.01043094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001685329,"threshold_uncertainty_score":0.005637944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02933188551592038,"score_gpt":0.3423311226975648,"score_spread":0.3129992371816445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}