{"id":"W3104946688","doi":"10.1186/s41181-020-00111-y","title":"Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting, 111In or β-particle emitting, 177Lu","year":2020,"lang":"en","type":"article","venue":"EJNMMI Radiopharmacy and Chemistry","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Foundation; University of Toronto; Canadian Cancer Society","keywords":"Panitumumab; DOTA; Radioimmunotherapy; Cancer research; Radionuclide therapy; Chemistry; Molecular biology; Medicine; Monoclonal antibody; Cetuximab; Internal medicine; Immunology; Biology; Antibody; Chelation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003079498,0.0003834135,0.00108511,0.00004644256,0.0001573238,0.00002777862,0.0002024058,0.0001172677,0.001402993],"category_scores_gemma":[0.00008845873,0.0002506129,0.00006496772,0.000615826,0.0003927886,0.0001133694,0.00004125975,0.0006590484,0.000004495929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001371932,"about_ca_system_score_gemma":0.0006913954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004226697,"about_ca_topic_score_gemma":0.00006051426,"domain_scores_codex":[0.9976109,0.00008250355,0.0005900273,0.0005727956,0.0004367782,0.000707057],"domain_scores_gemma":[0.9987426,0.0001849561,0.0002714196,0.0003049063,0.000128944,0.0003671807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01362677,0.0004037059,0.3432472,0.001425792,0.0005502471,0.000530155,0.0020457,0.000003907374,0.6368495,0.000003842897,0.0006038196,0.0007093676],"study_design_scores_gemma":[0.03127562,0.002028091,0.02481392,0.001539676,0.0009524953,0.0005302209,0.001137965,0.001266844,0.9328293,0.000004251329,0.003021814,0.0005998535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924693,0.005138879,0.00001332796,0.001020147,0.00001516301,0.0006480501,0.00001495848,0.00007466589,0.0006055518],"genre_scores_gemma":[0.9929301,0.002135502,0.0006372983,0.0005928298,0.0002551594,0.0001844207,0.00002186373,0.00006821704,0.003174603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3184333,"threshold_uncertainty_score":0.9999946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02933188551592038,"score_gpt":0.3423311226975648,"score_spread":0.3129992371816445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}