{"id":"W3105127887","doi":"10.1007/978-3-030-58677-5_8","title":"Sex-Specific Differences in β-Adrenoceptor Signal Transduction in Heart Failure Due to Volume-Overload","year":2020,"lang":"en","type":"book-chapter","venue":"","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Adenylyl cyclase; Internal medicine; Endocrinology; Pressure overload; Heart failure; Volume overload; Muscle hypertrophy; Epinephrine; Medicine; Biology; Receptor; Cardiac hypertrophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017056,0.0002584957,0.0002962789,0.000279743,0.0001244297,0.000458442,0.0003964932,0.0003210158,0.008004516],"category_scores_gemma":[0.00009440273,0.0001410959,0.0002176652,0.0002779498,0.0001876857,0.000398973,0.0002739966,0.0006373996,0.001971333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000190622,"about_ca_system_score_gemma":0.0001375882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003755746,"about_ca_topic_score_gemma":0.001001239,"domain_scores_codex":[0.9999682,0.000003292383,0.000001526875,0.000006646244,0.00001528835,0.000005093214],"domain_scores_gemma":[0.9999764,0.00001321326,0.000001893595,0.000001475248,0.000003391342,0.000003717499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000504781,0.0001828006,0.0009555101,0.0009451899,0.00004336945,0.00167931,0.0004453076,0.0009033329,0.3018757,0.05316425,0.05216809,0.5871324],"study_design_scores_gemma":[0.00004730927,0.0005734646,0.02470541,0.0003538941,0.0000879618,0.00901703,0.0002729735,0.001680203,0.07617946,0.04325878,0.8437604,0.00006314508],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.08037938,0.4512173,0.03446924,0.005125821,0.004340527,0.00007944494,0.001524369,0.0007755577,0.4220883],"genre_scores_gemma":[0.1547872,0.1818035,0.008039336,0.001606174,0.001281308,0.0000935596,0.0008599053,0.0002847948,0.6512444],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008004516,"threshold_uncertainty_score":0.0267778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0139273443552949,"score_gpt":0.2046703215341513,"score_spread":0.1907429771788564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}