{"id":"W3105152741","doi":"10.3390/cancers12113468","title":"Tumor BRCA Testing in High Grade Serous Carcinoma: Mutation Rates and Optimal Tissue Requirements","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto; Mount Sinai Hospital","funders":"Centro de Investigación Biomédica en Red de Cáncer; Women's College Hospital","keywords":"Serous fluid; Serous carcinoma; BRCA mutation; Medicine; Genetic testing; Oncology; Internal medicine; Cancer; Ovarian cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003090788,0.0002524535,0.000385051,0.0009342813,0.0001969013,0.0005988537,0.0003411968,0.0004694521,0.001019188],"category_scores_gemma":[0.009132633,0.0001552331,0.0001674114,0.0004439599,0.0004371181,0.000405738,0.000339589,0.000276856,0.0003363813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002693903,"about_ca_system_score_gemma":0.0002415532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005324579,"about_ca_topic_score_gemma":0.0006362792,"domain_scores_codex":[0.9986684,0.0005369298,0.0001817133,0.0001625179,0.0003313845,0.0001190404],"domain_scores_gemma":[0.9946108,0.003528576,0.001024481,0.000197603,0.0003507941,0.0002876785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001152196,0.00004585299,0.9667346,0.00009568869,0.00002864076,0.001037591,0.0001415677,0.001043845,0.01305057,0.00004816295,0.0001350673,0.01648615],"study_design_scores_gemma":[0.0000404816,0.001067084,0.957389,0.0000647378,0.00007973707,0.01339378,0.0003625524,0.003727292,0.02292775,0.0002151546,0.0007197178,0.00001273171],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974536,0.001216389,0.0008304973,0.00005463843,0.000002949343,0.00001090089,0.00006881736,0.000009855681,0.0003523691],"genre_scores_gemma":[0.9988042,0.0002328991,0.0008027453,0.0000204738,0.000006264549,0.000006876811,0.00009064082,0.000004468425,0.00003140036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003090788,"threshold_uncertainty_score":0.0163458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07036319199292808,"score_gpt":0.3338995633652542,"score_spread":0.2635363713723262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}