{"id":"W3105221305","doi":"10.1139/cjpp-2020-0246","title":"Ethanol and cyclophosphamide induce similar nephrotoxic effects: possible role for Nox4 and superoxide","year":2020,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Electrolyte and hormonal disorders","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Nephrotoxicity; Ethanol; Chemistry; Intraperitoneal injection; Toxicity; Pharmacology; NOX4; Superoxide dismutase; Saline; Superoxide; Cyclophosphamide; Kidney; Renal cortex; Endocrinology; Internal medicine; Reactive oxygen species; Oxidative stress; Biochemistry; Medicine; NADPH oxidase; Chemotherapy; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104682,0.0001363386,0.0003914158,0.0001031711,0.0001271361,0.000007248118,0.00005976293,0.0001525797,0.00008924262],"category_scores_gemma":[0.00006051742,0.0001199774,0.00005131375,0.00007719366,0.0002345976,0.00007547123,0.00001262183,0.000358346,0.000001116982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001846419,"about_ca_system_score_gemma":0.0004165667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001231084,"about_ca_topic_score_gemma":0.0001331201,"domain_scores_codex":[0.9992161,0.00006689064,0.0001961967,0.0001720746,0.00003477342,0.0003139147],"domain_scores_gemma":[0.9988638,0.0002019359,0.00007954772,0.00003540556,0.00007457615,0.0007447914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006553085,0.00001470774,0.002699102,0.0002328679,0.0002089753,0.00008675581,0.0005561609,0.00000335522,0.9906071,0.0001147199,0.002737451,0.002083488],"study_design_scores_gemma":[0.01059034,0.007712706,0.1404683,0.00006596201,0.0008537945,0.0007717605,0.0002830007,0.0003933565,0.8103808,0.008375811,0.01974655,0.0003577044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764064,0.0113804,0.00001328273,0.01166677,0.00007348385,0.0003268336,0.00001154569,0.000004458357,0.0001168522],"genre_scores_gemma":[0.9801312,0.001097537,0.0001246612,0.01830218,0.0002902541,0.00001257264,0.000004729359,0.00001437558,0.00002251213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1802264,"threshold_uncertainty_score":0.4892538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086174158605979,"score_gpt":0.2609598534549625,"score_spread":0.2500981118689027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}