{"id":"W3105254545","doi":"10.1158/1078-0432.ccr-20-2845","title":"AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":238,"is_retracted":false,"has_abstract":true,"ca_institutions":"Digital Payment Technologies (Canada)","funders":"Amgen","keywords":"Cancer research; Medicine; Cell; Lung cancer; Ligand (biochemistry); Small molecule; T cell; Oncology; Internal medicine; Receptor; Chemistry; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.008414973,0.0004724069,0.001931319,0.0003635692,0.0002503977,0.00006347625,0.0004281913,0.0005300268,0.0005858615],"category_scores_gemma":[0.005570857,0.0004057207,0.0003724127,0.001516273,0.001683693,0.0002195909,0.001215853,0.004980204,0.00002283393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005223888,"about_ca_system_score_gemma":0.00360205,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01001491,"about_ca_topic_score_gemma":0.003776318,"domain_scores_codex":[0.9899285,0.002654405,0.001919322,0.001853915,0.002089351,0.001554441],"domain_scores_gemma":[0.9906326,0.00511405,0.0002903727,0.0009389529,0.001360541,0.001663464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03532979,0.007590272,0.7524678,0.01477039,0.001665336,0.003248862,0.006367546,0.002654885,0.04844612,0.0006205225,0.06865942,0.05817907],"study_design_scores_gemma":[0.0637829,0.01073352,0.658531,0.004376822,0.001060957,0.00002944825,0.00396605,0.2149931,0.02572845,0.002067587,0.01188718,0.002842974],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.939313,0.0342399,0.0001818381,0.02076831,0.0003396539,0.002823093,0.0002339373,0.00009549858,0.002004766],"genre_scores_gemma":[0.9560607,0.03925446,0.0006836053,0.001125243,0.001112426,0.0005331397,0.00001935935,0.0001069769,0.001104078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2123382,"threshold_uncertainty_score":0.9998395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.307856614907692,"score_gpt":0.5039285427276453,"score_spread":0.1960719278199533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}