{"id":"W3105434842","doi":"10.1007/s40265-020-01429-2","title":"TRPV1-Targeted Drugs in Development for Human Pain Conditions","year":2020,"lang":"en","type":"review","venue":"Drugs","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":240,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Crohn's and Colitis Canada; Canada Excellence Research Chairs, Government of Canada","keywords":"TRPV1; Nociceptor; Medicine; Capsaicin; Chronic pain; Transient receptor potential channel; Neuropathic pain; Analgesic; Resiniferatoxin; Nociception; Noxious stimulus; Anesthesia; Pharmacology; Internal medicine; Receptor; Physical therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000562718,0.0004076634,0.00159452,0.0002461077,0.0001241527,0.00001651121,0.0001263251,0.0002407046,0.0001640162],"category_scores_gemma":[0.00009921972,0.0003343911,0.0003869583,0.0002825116,0.0000217852,0.00002597848,0.00003826098,0.0002638481,0.0001678187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004165735,"about_ca_system_score_gemma":0.0005727158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001597525,"about_ca_topic_score_gemma":0.000008993519,"domain_scores_codex":[0.9981581,0.0001641498,0.0006441153,0.000470132,0.0002164097,0.0003471152],"domain_scores_gemma":[0.9990881,0.0002313715,0.0001957428,0.0002501636,0.0000400681,0.0001945187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008172223,0.0002752798,0.000007624315,0.01068353,0.0004674354,0.00008140209,0.0009859342,2.849169e-8,0.000003475708,0.001167473,0.002543503,0.9837762],"study_design_scores_gemma":[0.001338021,0.0001122733,0.0000153628,0.007886421,0.0005675012,0.000006108396,0.0001297221,0.00000509262,0.00001634647,0.0003366723,0.9893056,0.0002809026],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003368022,0.9948241,0.0001890442,0.0001631445,0.0001266656,0.003109701,0.0001654784,0.0001033951,0.001284821],"genre_scores_gemma":[0.0003602825,0.9806798,0.004275702,0.0006013148,0.0002137405,0.002845943,0.008170059,0.0001365618,0.002716619],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.986762,"threshold_uncertainty_score":0.9999108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0501895548727496,"score_gpt":0.3641805341924365,"score_spread":0.3139909793196868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}