{"id":"W3105478020","doi":"10.1101/2020.07.13.201509","title":"SARS-CoV-2 infects cells following viral entry via clathrin-mediated endocytosis","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Royal Society; ALS Society of Canada; McGill University; Royal Society of Canada; University of Washington","keywords":"Endocytosis; Clathrin; Infectivity; Viral entry; Glycoprotein; Endosome; Virology; Cell biology; Receptor-mediated endocytosis; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Internalization; Coronavirus disease 2019 (COVID-19); Lipid raft; Gene knockdown; Cell; Virus; Cell culture; Molecular biology; Medicine; Viral replication; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.0007741403,0.001305068,0.001852994,0.000798601,0.0002546927,0.0003669148,0.001020507,0.001357572,0.00002174549],"category_scores_gemma":[0.0009197548,0.001389595,0.0009868367,0.001386722,0.0002244356,0.0002699221,0.0015102,0.003100581,0.001263214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009736347,"about_ca_system_score_gemma":0.002467103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000305074,"about_ca_topic_score_gemma":0.000006300105,"domain_scores_codex":[0.99304,0.000307574,0.001172761,0.002234602,0.001592898,0.001652229],"domain_scores_gemma":[0.9960231,0.0003053437,0.0005128058,0.002231533,0.0005516495,0.0003755606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002697772,0.0003884849,0.02285184,0.001186707,0.0008483595,0.002139866,0.00003240662,0.000001154552,0.9711419,0.00004888696,0.001081568,0.000009055852],"study_design_scores_gemma":[0.002865115,0.0002796738,0.01027712,0.0008196681,0.0005114367,1.471297e-7,0.000003279228,0.0007214422,0.9381516,0.000004703423,0.04518954,0.001176293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908465,0.001637709,0.0009592033,0.000455898,0.002302028,0.002155888,0.0001689203,0.001314115,0.000159701],"genre_scores_gemma":[0.9720393,0.00009055022,0.001342691,0.02431962,0.001382369,0.0004209023,0.000001524222,0.000401007,0.000002022702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04410797,"threshold_uncertainty_score":0.9999701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896018956807371,"score_gpt":0.2853374937161233,"score_spread":0.2563773041480495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}