{"id":"W3105478020","doi":"10.1101/2020.07.13.201509","title":"SARS-CoV-2 infects cells following viral entry via clathrin-mediated endocytosis","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Royal Society; ALS Society of Canada; McGill University; Royal Society of Canada; University of Washington","keywords":"Endocytosis; Clathrin; Infectivity; Viral entry; Glycoprotein; Endosome; Virology; Cell biology; Receptor-mediated endocytosis; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Internalization; Coronavirus disease 2019 (COVID-19); Lipid raft; Gene knockdown; Cell; Virus; Cell culture; Molecular biology; Medicine; Viral replication; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399922,0.0002039514,0.0001521231,0.0001591245,0.0002337832,0.0004154453,0.0001230803,0.0002972174,0.003979009],"category_scores_gemma":[0.0001004,0.00009588355,0.0002207227,0.0001386802,0.000144786,0.0002321091,0.0002308386,0.0004389292,0.001981705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005135466,"about_ca_system_score_gemma":0.0003514853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00165618,"about_ca_topic_score_gemma":0.001550068,"domain_scores_codex":[0.9998993,0.000008589565,0.000005031355,0.00001398309,0.00004875211,0.00002439078],"domain_scores_gemma":[0.9999701,0.000005924543,0.000004041656,0.000005072646,0.00000856684,0.000006254408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002138849,0.0000355148,0.001288868,0.00006972604,0.00001675685,0.0001926357,0.000045907,0.0001717227,0.9909589,0.001825484,0.001585992,0.003594449],"study_design_scores_gemma":[0.00006155785,0.0001793939,0.01980454,0.00002342273,0.00001514579,0.0008904564,0.0001005091,0.00527771,0.9437149,0.00094535,0.02896967,0.00001734232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9531021,0.004138148,0.01014571,0.001110555,0.0002622147,0.0001180708,0.002603852,0.0002889077,0.02823041],"genre_scores_gemma":[0.9635941,0.001845893,0.004718761,0.0002387121,0.00006042387,0.00004754095,0.003114715,0.00004969881,0.02633007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003979009,"threshold_uncertainty_score":0.01331109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896018956807371,"score_gpt":0.2853374937161233,"score_spread":0.2563773041480495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}