{"id":"W3105523962","doi":"10.1098/rsos.200958","title":"ACE inhibition and cardiometabolic risk factors, lung <i>ACE2</i> and <i>TMPRSS2</i> gene expression, and plasma ACE2 levels: a Mendelian randomization study","year":2020,"lang":"en","type":"article","venue":"Royal Society Open Science","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; St. Paul's Hospital; University of British Columbia","funders":"National Cancer Institute; NIH Office of the Director; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; Economic and Social Research Council; Engineering and Physical Sciences Research Council; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; National Institutes of Health; Vetenskapsrådet; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Health and Social Care Research and Development Division; Cambridge University Hospitals; Hjärt-Lungfonden; Public Health Agency; Common Fund; Imperial College London; NIHR BioResource; Royal Society; NHS Blood and Transplant; National Institute for Health and Care Research; British Heart Foundation; Leidos; University of Cambridge; Wellcome Trust; Cancer Research UK; Medical Research Council; Department of Health and Social Care; European Commission; Broad Institute; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Scottish Government; UK Research and Innovation; Université Laval","keywords":"TMPRSS2; Mendelian randomization; Angiotensin-converting enzyme 2; Biology; Internal medicine; TMPRSS6; Endocrinology; Immunology; Medicine; Disease; Gene; Genetics; Genotype; Serine protease; Protease; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003403373,0.000702774,0.0007255842,0.0004899503,0.000278893,0.0006302044,0.0005375643,0.0007396039,0.001655226],"category_scores_gemma":[0.005396325,0.0004327971,0.001532425,0.0006170021,0.0004581535,0.0002662008,0.0003183068,0.0005765197,0.00015044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002878529,"about_ca_system_score_gemma":0.0004071099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002051998,"about_ca_topic_score_gemma":0.0009580928,"domain_scores_codex":[0.9970902,0.001679313,0.0001600596,0.0006177979,0.0002765337,0.0001759738],"domain_scores_gemma":[0.9967151,0.001274344,0.0007625658,0.0008055117,0.0001101499,0.0003323464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07334152,0.001437097,0.8890622,0.0001235539,0.006915512,0.001037773,0.0001998464,0.00135516,0.01487135,0.0008594379,0.0006064521,0.01019015],"study_design_scores_gemma":[0.004547556,0.01009419,0.9658229,0.00001957086,0.004069784,0.00171058,0.0001143136,0.009170251,0.002374313,0.0009047226,0.001097622,0.00007432388],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982429,0.0001775647,0.0009594098,0.00005240266,0.00001306722,0.00003184462,0.0002517204,0.00001486916,0.0002561755],"genre_scores_gemma":[0.9986901,0.00005372074,0.0006664323,0.00004523356,0.00001331788,0.00004375962,0.0002109192,0.000007010687,0.0002695115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003403373,"threshold_uncertainty_score":0.01799893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05097111499298895,"score_gpt":0.3823218556323025,"score_spread":0.3313507406393135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}