{"id":"W3105523962","doi":"10.1098/rsos.200958","title":"ACE inhibition and cardiometabolic risk factors, lung <i>ACE2</i> and <i>TMPRSS2</i> gene expression, and plasma ACE2 levels: a Mendelian randomization study","year":2020,"lang":"en","type":"article","venue":"Royal Society Open Science","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; St. Paul's Hospital; University of British Columbia","funders":"National Cancer Institute; NIH Office of the Director; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; NIHR Cambridge Biomedical Research Centre; Economic and Social Research Council; Engineering and Physical Sciences Research Council; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; National Institutes of Health; Vetenskapsrådet; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Health and Social Care Research and Development Division; Cambridge University Hospitals; Hjärt-Lungfonden; Public Health Agency; Common Fund; Imperial College London; NIHR BioResource; Royal Society; NHS Blood and Transplant; National Institute for Health and Care Research; British Heart Foundation; Leidos; University of Cambridge; Wellcome Trust; Cancer Research UK; Medical Research Council; Department of Health and Social Care; European Commission; Broad Institute; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Scottish Government; UK Research and Innovation; Université Laval","keywords":"TMPRSS2; Mendelian randomization; Angiotensin-converting enzyme 2; Biology; Internal medicine; TMPRSS6; Endocrinology; Immunology; Medicine; Disease; Gene; Genetics; Genotype; Serine protease; Protease; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002798823,0.0002305859,0.0006494655,0.00004644993,0.001031589,0.0003808966,0.0002908205,0.00008040305,0.00001576864],"category_scores_gemma":[0.008785807,0.0001702834,0.00007850458,0.0008458435,0.0009102973,0.0004907403,0.002258705,0.0003497732,0.000001708344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007791702,"about_ca_system_score_gemma":0.0002871703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003393617,"about_ca_topic_score_gemma":0.000009338653,"domain_scores_codex":[0.9970552,0.0001991889,0.0003676627,0.0009894189,0.0009749879,0.0004135288],"domain_scores_gemma":[0.9975773,0.001109283,0.0001489116,0.0002684524,0.0002504056,0.0006456349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00139291,0.0004609282,0.8070068,0.0004802074,0.000373015,0.00002347731,0.0449018,0.0006382187,0.1274682,0.00001762675,0.007953172,0.009283661],"study_design_scores_gemma":[0.06531662,0.00226102,0.7122254,0.0003611099,0.0009641425,0.000006991898,0.02241473,0.143374,0.04339906,0.000106336,0.008335945,0.001234627],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914054,0.0005236904,0.002248131,0.003434053,0.00005031655,0.002132607,0.00007674913,0.00004483492,0.00008426291],"genre_scores_gemma":[0.9950524,0.001562131,0.002078914,0.001010387,0.00009407891,0.00006365521,0.000005833287,0.00001571199,0.0001168655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1427358,"threshold_uncertainty_score":0.9995636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05097111499298895,"score_gpt":0.3823218556323025,"score_spread":0.3313507406393135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}